Introduction: Current treatment of osteosarcoma includes surgical resection of all gross
disease in conjunction with systemic chemotherapy to control micro-metastatic disease. This …

Long-term outcome for patients with high-grade osteosarcoma has improved with the
addition of systemic chemotherapy, but subsequent progress has been less marked …

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), one of the first found
cancer-associated long noncoding RNAs (lncRNAs), involves in the development and …

Despite significant advancements in the diagnosis and treatment of osteosarcoma to date,
overall survival has remained relatively constant for over 2 decades. The challenge in …

Osteosarcomas are sarcomas of the bone, derived from osteoblasts or their precursors, with
a high propensity to metastasize. Osteosarcoma is associated with massive genomic …

Background The current study aims to determine cause-specific survival in patients with high-
grade osteosarcoma while reporting risk factors for decreased survival out to 10 years …

Osteosarcoma is a primary bone malignancy that typically occurs during adolescence but
also has a second incidence peak in the elderly. It occurs most commonly in the long bones …

Osteosarcoma (OS) is a class of cancer originating from bone, mainly afflicting children or
young adults. It is the second highest cause of cancer-related death in these age groups …

Mutation of the retinoblastoma gene (RB1) tumour suppressor occurs in one-third of all
human tumours and is particularly associated with retinoblastoma and osteosarcoma …

Methods: HBO1 expression was tested in human OS tissues and cells. Genetic strategies,
including shRNA, CRISPR/Cas9 and overexpression constructs, were applied to …