Over 30 million people suffer from the consequences of ischemic stroke. The precise
molecular mechanism of neuronal damage during ischemic stroke remains unclear; …

Stroke remains a significant unmet clinical need with few treatment options that have a very
narrow therapeutic window, thereby causing massive mortality and morbidity in the United …

Brain iron homeostasis is maintained through the normal function of blood–brain barrier and
iron regulation at the systemic and cellular levels, which is fundamental to normal brain …

Chronic (neuro) inflammation plays an important role in many age-related central nervous
system (CNS) diseases, including Alzheimer's disease, Parkinson's disease and vascular …

Stroke is the leading cause of death and disability after ischemic heart disease. However,
there is lacking a non-invasive long-time monitoring technique for stroke diagnosis and …

The clinical diagnosis of vascular dementia (VaD) is based on imaging criteria, and specific
biochemical markers are not available. Here, we investigated the potential of cerebrospinal …

Background Cerebral malaria is a common presentation of severe Plasmodium falciparum
infection and remains an important cause of death in the tropics. Key aspects of its …

Stroke is the second leading cause of death worldwide; however, the treatment choices
available to neurologists are limited in clinical practice. Lipocalin 2 (LCN2) is a secreted …

Salidroside has been shown to exert neuroprotective effects against hypoxia. However, its
mitochondrial protective mechanisms still remain elusive. The present study aimed to …

Amyotrophic lateral sclerosis (ALS) is an adult-onset paralytic disease characterized by
progressive degeneration of upper and lower motor neurons in the motor cortex, brainstem …