Protein synthesis is frequently dysregulated in cancer and selective inhibition of mRNA
translation represents an attractive cancer therapy. Here, we show that therapeutically …

The macrophages contribute to host defense against intracellular pathogens such as
mycobacteria. Mycobacteria interact with macrophages altering their polarization state …

Since many human diseases are caused by the unwelcome production of harmful proteins,
compounds that selectively suppress protein synthesis should provide a unique path for …

Mycobacterium tuberculosis (Mtb) and HIV are known to mutually support each other during
co-infection by multiple mechanisms. This synergistic influence could be either by direct …

At present, surgical debridement and systematic administration of antibiotics represent the
mainstay of treatment for chronic osteomyelitis. However, it is now understood that …

Understanding cell state transitions and purposefully controlling them to improve therapies
is a longstanding challenge in biological research and medicine. Here, we identify a …

Objective Bovine tuberculosis (bTB) is a chronic respiratory infectious disease of domestic
livestock caused by intracellular Mycobacterium bovis infection, which causes~ $3 billion in …

c-Myc (Myc) is a well-known transcription factor that regulates many essential cellular
processes. Myc has been implicated in regulating anti-mycobacterial responses. However …

Mycobacterial membrane proteins play a pivotal role in the bacterial invasion of host cells;
however, the precise mechanisms underlying certain membrane proteins remain elusive …

Macrophages can exhibit pro-inflammatory or pro-reparatory functions, contingent upon their
specific activation state. This dynamic behavior empowers macrophages to engage in …