The interrelations between inflammation and regeneration are of particular significance
within the dental pulp tissue inextensible environment. Recent data have demonstrated the …

Neuroinflammation is a central feature of Alzheimer disease (AD). It involves an innate
immune reaction of sufficient intensity that self attack on neurons occurs. This phenomenon …

Abstract mdash;: An intact innate and acquired immune response are essential for defeating
systemic microbial infections. Recognition molecules, inflammatory cells, and the cytokines …

We have examined the complement-activating properties of synthetic cationic molecules
and their complexes with DNA. Commonly used gene delivery vehicles include complexes …

Choroidal neovascularization (CNV), or choroidal angiogenesis, is the hallmark of age-
related macular degeneration and a leading cause of visual loss after age 55. The …

The molecular cloning of the C5a receptor places this molecule in the superfamily of G-
protein coupled receptors. This superfamily is characterized by the presence of signature …

▪ Abstract Recent results obtained in mice deficient in either FcRs or complement have
revealed distinct functions for these two classes of molecules. While each is capable of …

Since we live in a dirty environment, we have developed many host defenses to contend
with microorganisms. The epithelial lining of our skin, gastrointestinal tract and bronchial …

Complement is an important effector mechanism for antibody-mediated clearance of
infections and tumor cells. Upon binding to target cells, the antibody's constant (Fc) domain …

Microglia and macrophages, one a brain-resident, the other a mostly hematogenous cell
type, represent two related cell types involved in the brain pathology in multiple sclerosis …