Molecular mechanisms of antibiotic resistance revisited

EM Darby, E Trampari, P Siasat, MS Gaya… - Nature Reviews …, 2023 - nature.com
Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics
currently in clinical use and only a few novel drugs in the pipeline. Understanding the …

Staphylococcus aureus host interactions and adaptation

BP Howden, SG Giulieri, T Wong Fok Lung… - Nature Reviews …, 2023 - nature.com
Invasive Staphylococcus aureus infections are common, causing high mortality,
compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an …

Bacterial defences: mechanisms, evolution and antimicrobial resistance

WPJ Smith, BR Wucher, CD Nadell… - Nature Reviews …, 2023 - nature.com
Throughout their evolutionary history, bacteria have faced diverse threats from other
microorganisms, including competing bacteria, bacteriophages and predators. In response …

Membrane-Targeting Neolignan-Antimicrobial Peptide Mimic Conjugates to Combat Methicillin-Resistant Staphylococcus aureus (MRSA) Infections

R Yang, E Hou, W Cheng, X Yan, T Zhang… - Journal of Medicinal …, 2022 - ACS Publications
Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) continue to
endanger public health. Here, we report the synthesis of neolignan isomagnolone (I) and its …

Latent antibiotic resistance genes are abundant, diverse, and mobile in human, animal, and environmental microbiomes

JS Inda-Díaz, D Lund, M Parras-Moltó, A Johnning… - Microbiome, 2023 - Springer
Background Bacterial communities in humans, animals, and the external environment
maintain a large collection of antibiotic resistance genes (ARGs). However, few of these …

Role of bacterial efflux pumps in antibiotic resistance, virulence, and strategies to discover novel efflux pump inhibitors

A Gaurav, P Bakht, M Saini, S Pandey… - …, 2023 - microbiologyresearch.org
The problem of antibiotic resistance among pathogenic bacteria has reached a crisis level.
The treatment options against infections caused by multiple drug-resistant bacteria are …

Antimicrobial resistance: a concise update

CS Ho, CTH Wong, TT Aung… - The Lancet …, 2024 - thelancet.com
Antimicrobial resistance (AMR) is a serious threat to global public health, with approximately
5 million deaths associated with bacterial AMR in 2019. Tackling AMR requires a …

Joining forces against antibiotic resistance: The one health solution

E Cella, M Giovanetti, F Benedetti, F Scarpa… - Pathogens, 2023 - mdpi.com
Antibiotic resistance is a significant global health concern that affects both human and
animal populations. The One Health approach acknowledges the interconnectedness of …

Phages against pathogenic bacterial biofilms and biofilm-based infections: a review

S Liu, H Lu, S Zhang, Y Shi, Q Chen - Pharmaceutics, 2022 - mdpi.com
Bacterial biofilms formed by pathogens are known to be hundreds of times more resistant to
antimicrobial agents than planktonic cells, making it extremely difficult to cure biofilm-based …

Multiclonal human origin and global expansion of an endemic bacterial pathogen of livestock

G Yebra, JD Harling-Lee, S Lycett… - Proceedings of the …, 2022 - National Acad Sciences
Most new pathogens of humans and animals arise via switching events from distinct host
species. However, our understanding of the evolutionary and ecological drivers of …