Oxidative stress-induced damage to the retinal pigment epithelium (RPE) is considered to
be a key factor in age-related macular degeneration (AMD) pathology. RPE cells are …

The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells,
strategically situated between the photoreceptors and the choroid, is the primary caretaker of …

The retinal pigment epithelium (RPE) is a highly specialized, unique epithelial cell that
interacts with photoreceptors on its apical side and with Bruch's membrane and the …

Age-related macular degeneration (AMD) is a disease that affects the macula–the central
part of the retina. It is a leading cause of irreversible vision loss in the elderly. AMD onset is …

Aging is the greatest risk factor for chronic human diseases, including many eye diseases.
Geroscience aims to understand the effects of the aging process on these diseases …

Gene therapies aim to deliver a therapeutic payload to specified tissues with underlying
protein deficiency. Since the 1990s, gene therapies have been explored as potential …

The complement system is crucial for immune surveillance, providing the body's first line of
defence against pathogens. However, an imbalance in its regulators can lead to …

Oxidative stress is hypothesized to drive the progression of age-related macular
degeneration (AMD). Retinal pigment epithelial (RPE) cell layer is important for supporting …

Balancing the competing demands of phagolysosomal degradation and autophagy is a
significant challenge for phagocytic tissues. Yet how this plasticity is accomplished in health …

Purpose: To quantify organelles impacting imaging in the cell body and intact apical
processes of human retinal pigment epithelium (RPE), including melanosomes, lipofuscin …