Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

Importance Harms and benefits of opioids for chronic noncancer pain remain unclear.
Objective To systematically review randomized clinical trials (RCTs) of opioids for chronic …

Objective To assess the effectiveness and safety of different preparations and doses of non-
steroidal anti-inflammatory drugs (NSAIDs), opioids, and paracetamol for knee and hip …

Chronic pain causes significant suffering, limitation of daily activities and reduced quality of
life. Infection from COVID‐19 is responsible for an ongoing pandemic that causes severe …

Background Chronic pain is common and can be challenging to manage. Despite increased
utilisation of opioids, the safety and efficacy of long‐term use of these compounds for chronic …

Background The objective of this review was to merge current treatment guidelines and best
practice recommendations for management of neuropathic pain into a comprehensive …

Acute kidney injury (AKI), once viewed predominantly as a self-limited and reversible
condition, is now recognized as a growing problem associated with significant risks of …

Background A significant number of patients use opioids prior to total joint arthroplasty (TJA)
in North America and there is growing concern that preoperative opioid use negatively …

Background The definition, classification and management of rectus diastasis (RD) are
controversial in the literature and a variety of different surgical treatments have been …

Objective To determine the effects of medical cannabinoids on pain, spasticity, and nausea
and vomiting, and to identify adverse events. Data sources MEDLINE, the Cochrane …