The reservoir of persistent human papillomavirus infection; strategies for elimination using anti-viral therapies

K Zheng, N Egawa, A Shiraz, M Katakuse, M Okamura… - Viruses, 2022 - mdpi.com
Human Papillomaviruses have co-evolved with their human host, with each of the over 200
known HPV types infecting distinct epithelial niches to cause diverse disease pathologies …

Genetic variability of the HPV16 early genes and LCR. Present and future perspectives

G Bletsa, F Zagouri, GD Amoutzias… - Expert Reviews in …, 2021 - cambridge.org
Human papillomavirus 16 (HPV16) infection is the aetiologic factor for the development of
cervical dysplasia and is regarded as highly carcinogen, because it is implicated in more …

HPV E6 inhibits E6AP to regulate epithelial homeostasis by modulating keratinocyte differentiation commitment and YAP1 activation

W Yin, N Egawa, K Zheng, H Griffin, P Tian… - PLoS …, 2023 - journals.plos.org
Human papillomaviruses (HPV) cause persistent infections by modulating epithelial
homeostasis in cells of the infected basal layer. Using FUCCI and cell-cell competition …

Classification of high‐grade cervical intraepithelial neoplasia by p16ink4a, Ki‐67, HPV E4 and FAM19A4/miR124‐2 methylation status demonstrates considerable …

FJ Vink, S Dick, DAM Heideman… - … journal of cancer, 2021 - Wiley Online Library
High‐grade cervical intraepithelial neoplasia (CIN2 and CIN3) represents a heterogeneous
disease with varying cancer progression risks. Biomarkers indicative for a productive human …

Detection of cervical cells based on improved SSD network

D Jia, J Zhou, C Zhang - Multimedia Tools and Applications, 2022 - Springer
Cervical cancer has influenced life of women worldwide as the fourth most severe cancer.
Early screening, detection and treatment of cervical cancer notably increase the life quality …

Performance of DNA methylation analysis of ASCL1, LHX8, ST6GALNAC5, GHSR, ZIC1 and SST for the triage of HPV‐positive women: Results from a Dutch primary …

L Verhoef, MCG Bleeker, N Polman… - … journal of cancer, 2022 - Wiley Online Library
Methylation of host‐cell deoxyribonucleic acid (DNA) has been proposed as a promising
biomarker for triage of high‐risk (hr) human papillomavirus (HPV) positive women at …

Identification of a Ferroptosis‐related prognostic gene PTGS2 based on risk modeling and immune microenvironment of early‐stage cervical cancer

C Zou, F Xu, J Shen, S Xu - Journal of oncology, 2022 - Wiley Online Library
Background. Cervical cancer (CC) has long been a concern, as a gynecological cancer type
of high‐risk. At present, there are few studies on the early detection of CC at the genetic …

Cervical cell/clumps detection in cytology images using transfer learning

C Xu, M Li, G Li, Y Zhang, C Sun, N Bai - Diagnostics, 2022 - mdpi.com
Cervical cancer is one of the most common and deadliest cancers among women and poses
a serious health risk. Automated screening and diagnosis of cervical cancer will help …

A systematic review and meta-analysis of the diagnostic effectiveness of human papillomavirus methylation biomarkers for detection of cervical cancer

CRT Hillyar, SS Kanabar, KR Pufal, AW Lawson… - …, 2022 - Taylor & Francis
Background: The aim of this systematic review and meta-analysis was to assess the
evidence for the diagnostic effectiveness of human papillomavirus (HPV) methylation …

Cervical cell lift: A novel triage method for the spatial mapping and grading of precancerous cervical lesions

A Shiraz, N Egawa, DM Pelt, R Crawford… - …, 2022 - thelancet.com
Background Primary HPV screening, due to its low specificity, requires an additional liquid-
based cytology (LBC) triage test. However, even with LBC triage there has been a near …