Type I collagen is the most abundant structural protein in vertebrates. It is a heterotrimeric
molecule composed of two α1 chains and one α2 chain, forming a long uninterrupted triple …

Aortic aneurysm is common, accounting for 1–2% of all deaths in industrialized countries.
Early theories of the causes of human aneurysm mostly focused on inherited or acquired …

PURPOSE: Higher serum levels of the main circulating form of vitamin D, 25-hydroxyvitamin
D (25 (OH) D), are associated with substantially lower incidence rates of colon, breast …

Heterotrimers composed of collagen type IV alpha 1 (COL4A1) and alpha 2 (COL4A2)
constitute one of the most abundant components of nearly all basement membranes …

The vertebrate collagen superfamily now includes over 50 collagens and collagen-like
proteins. Here, their different structures are described, as well as their diverse forms of …

Collagen is a macromolecule that has versatile roles in physiology, ranging from structural
support to mediating cell signaling. Formation of mature collagen fibrils out of procollagen α …

Wound healing is one of the most complex processes in multicellular organisms, involving
numerous intra-and intercellular signalling pathways in various cell types. It involves …

Extracellular matrix (ECM) proteins create structural frameworks in tissues such as bone,
skin, tendon and cartilage etc. These connective tissues play important roles in the …

Cells in multicellular organisms are surrounded by a complex three-dimensional
macromolecular extracellular matrix (ECM). This matrix, traditionally thought to serve a …

Collagens are the most abundant proteins in the extracellular matrix. They provide a
framework to build organs and tissues and give structural support to make them resistant to …