The role of neurod genes in brain development, function, and disease
S Tutukova, V Tarabykin… - Frontiers in Molecular …, 2021 - frontiersin.org
Transcriptional regulation is essential for the correct functioning of cells during development
and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is …
and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is …
[HTML][HTML] Making neurons, made easy: The use of Neurogenin-2 in neuronal differentiation
Directed neuronal differentiation of human pluripotent stem cells (hPSCs), neural
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …
Early Alzheimer's disease pathology in human cortex involves transient cell states
Cellular perturbations underlying Alzheimer's disease (AD) are primarily studied in human
postmortem samples and model organisms. Here, we generated a single-nucleus atlas from …
postmortem samples and model organisms. Here, we generated a single-nucleus atlas from …
APOE4 causes widespread molecular and cellular alterations associated with Alzheimer's disease phenotypes in human iPSC-derived brain cell types
Summary The apolipoprotein E4 (APOE4) variant is the single greatest genetic risk factor for
sporadic Alzheimer's disease (sAD). However, the cell-type-specific functions of APOE4 in …
sporadic Alzheimer's disease (sAD). However, the cell-type-specific functions of APOE4 in …
Orthogonally induced differentiation of stem cells for the programmatic patterning of vascularized organoids and bioprinted tissues
The generation of organoids and tissues with programmable cellular complexity,
architecture and function would benefit from the simultaneous differentiation of human …
architecture and function would benefit from the simultaneous differentiation of human …
SUPPA2: fast, accurate, and uncertainty-aware differential splicing analysis across multiple conditions
Despite the many approaches to study differential splicing from RNA-seq, many challenges
remain unsolved, including computing capacity and sequencing depth requirements. Here …
remain unsolved, including computing capacity and sequencing depth requirements. Here …
GPNMB confers risk for Parkinson's disease through interaction with α-synuclein
Many risk loci for Parkinson's disease (PD) have been identified by genome-wide
association studies (GWASs), but target genes and mechanisms remain largely unknown …
association studies (GWASs), but target genes and mechanisms remain largely unknown …
L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
M Norman, D Ter-Ovanesyan, W Trieu, R Lazarovits… - Nature …, 2021 - nature.com
L1CAM is a transmembrane protein expressed on neurons that was presumed to be found
on neuron-derived extracellular vesicles (NDEVs) in human biofluids. We developed a …
on neuron-derived extracellular vesicles (NDEVs) in human biofluids. We developed a …
A comprehensive library of human transcription factors for cell fate engineering
AHM Ng, P Khoshakhlagh, JE Rojo Arias… - Nature …, 2021 - nature.com
Human pluripotent stem cells (hPSCs) offer an unprecedented opportunity to model diverse
cell types and tissues. To enable systematic exploration of the programming landscape …
cell types and tissues. To enable systematic exploration of the programming landscape …
Transcription factor–mediated differentiation of human iPSCs into neurons
MS Fernandopulle, R Prestil… - Current protocols in …, 2018 - Wiley Online Library
Accurate modeling of human neuronal cell biology has been a long‐standing challenge.
However, methods to differentiate human induced pluripotent stem cells (iPSCs) to neurons …
However, methods to differentiate human induced pluripotent stem cells (iPSCs) to neurons …