The ubiquitous nature of the IGF system, expressed early in embryonic development
throughout postnatal and adult life, indicates a key role for this system in human biology …

The activity of the Insulin-like Growth Factors (IGFs) ligands elicited via their receptors and
transduced by various intracellular signal pathways is modulated by the IGF Binding …

Insulin-like growth factor-binding protein (IGFBP)-2 is a circulating biomarker of
cardiometabolic health. Here, we report that circulating IGFBP-2 concentrations robustly …

Bariatric surgery restores glucose tolerance in many, but not all, severely obese subjects
with type 2 diabetes (T2D). We aimed to evaluate the plasma protein profiles associated with …

Background The overall survival of IDH‐wildtype glioblastoma patients is poor despite best
available treatments. There is an urgent need for new biomarkers to inform more precise …

Glycosylation is co‐and posttranslational modifications affecting proteins. The glycopattern
changes are associated with changes in biological function and are involved in many …

The intention of this work was to systematically study the presence of insulin-like growth
factor-binding protein 1 and 2 (IGFBP-1 and IGFBP-2) complexes with alpha-2 …

The components of the insulin-like growth factor (IGF) system and molecules with which they
interact are associated with the neoplastic transformation of cells in colorectal cancer. The …

Abstract Alpha-2-macroglobulin (α2M) is a molecule generally associated with inflammation,
and chronic inflammation is associated with ageing and cancer. The degree of inflammation …

Aging is considered to be an adaptive mechanism to altered needs of an organism and/or to
altered stimuli. Plasma concentrations of insulin-like growth factor binding protein-2 (IGFBP …