There is a vital need for authentic COVID-19 animal models to enable the pre-clinical
evaluation of candidate vaccines and therapeutics. Here we report a dose titration study of …

Introduction: One of the essential mechanisms of virus infection control is cell-mediated
cytotoxicity, which can act in an antibody-dependent or-independent fashion and is provided …

Ferrets are a well‐established model for studying both the pathogenesis and transmission of
human respiratory viruses and evaluation of antiviral vaccines. Advanced immunological …

A key to improving vaccine design and vaccination strategy is to understand the mechanism
behind the variation of vaccine response with host factors. Glycosylation, a critical modulator …

In December 2019 an outbreak of coronavirus disease (COVID-19) emerged in Wuhan,
China. The causative agent was subsequently identified and named severe acute …

Host genetic factors play a fundamental role in regulating humoral immunity to viral infection,
including influenza A virus (IAV). Here, we utilize the Collaborative Cross (CC), a mouse …

An effective universal vaccine for influenza will likely need to induce virus-specific T-cells,
which are the major mediator of heterosubtypic cross-protection between different subtypes …

The development of universal influenza vaccines has been a priority for more than 20 years.
We conducted a preclinical study in ferrets of two sets of live attenuated influenza vaccines …

The initial exposure to influenza virus usually occurs during childhood. This imprinting has
long-lasting effects on the immune responses to subsequent infections and vaccinations …

Animal models of influenza are important in preclinical research for the study of influenza
infection and the assessment of vaccines, drugs and therapeutics. Here, we show that …