Promising technologies in the field of helminth vaccines

DJ Perera, M Ndao - Frontiers in immunology, 2021 - frontiersin.org
Helminths contribute a larger global burden of disease than both malaria and tuberculosis.
These eukaryotes have caused human infections since before our earliest recorded history …

[HTML][HTML] Advancement in Diagnosis, Treatment, and Vaccines against Fasciola hepatica: A Comprehensive Review

PJ Rufino-Moya, R Zafra Leva, Á Martínez-Moreno… - Pathogens, 2024 - mdpi.com
In this review article, we aim to provide an overview of fasciolosis in ruminants. Diagnosis
through new coprological methods (such as Flukefinder®, FLOTAC®, and Mini-FLOTAC®) …

Sex—the most underappreciated variable in research: insights from helminth-infected hosts

A Wesołowska - Veterinary Research, 2022 - Springer
The sex of a host affects the intensity, prevalence, and severity of helminth infection. In many
cases, one sex has been found to be more susceptible than the other, with the prevalence …

Proteomic analysis of exosome-like vesicles from Fasciola gigantica adult worm provides support for new vaccine targets against fascioliasis

ZA Sheng, CL Wu, DY Wang, SH Zhong, X Yang… - Parasites & …, 2023 - Springer
Abstract Background Extracellular vesicles (EVs) released by helminths play an important
role in parasite-host communication. However, little is known about the characteristics and …

Trained immunity: a cutting edge approach for designing novel vaccines against parasitic diseases?

J Zhu, J Liu, C Yan, D Wang, W Pan - Frontiers in Immunology, 2023 - frontiersin.org
The preventive situation of parasitosis, a global public health burden especially for
developing countries, is not looking that good. Similar to other infections, vaccines would be …

Pathological, immunological and parasitological study of sheep vaccinated with the recombinant protein 14-3-3z and experimentally infected with Fasciola hepatica

R Pérez-Caballero, M Siles-Lucas… - Veterinary immunology …, 2018 - Elsevier
In this study, the immunogenicity and protective capacity of a new recombinant vaccine
candidate, the rFh14-3-3z protein was analysed in sheep experimentally challenged with …

Targeting Kinases in Fasciola hepatica: Anthelminthic Effects and Tissue Distribution of Selected Kinase Inhibitors

CM Morawietz, H Houhou, O Puckelwaldt… - Frontiers in Veterinary …, 2020 - frontiersin.org
Protein kinases have been discussed as promising druggable targets in various parasitic
helminths. New drugs are also needed for control of fascioliasis, a food-borne trematode …

Intranasal delivery of a formulation containing stage-specific recombinant proteins of Fasciola hepatica cathepsin L5 and cathepsin B2 triggers an anti-fecundity effect …

LJ Norbury, K Basałaj, A Zawistowska-Deniziak… - Veterinary …, 2018 - Elsevier
Fasciola hepatica infection continues to be a major problem in the agriculture sector,
particularly in sheep and cattle. Cathepsin L and B proteases are major components of the …

A Preliminary Study of a Lettuce-Based Edible Vaccine Expressing the Cysteine Proteinase of Fasciola hepatica for Fasciolosis Control in Livestock

A Wesołowska, M Kozak Ljunggren, L Jedlina… - Frontiers in …, 2018 - frontiersin.org
Oral vaccination with edible vaccines is one of the most promising approaches in modern
vaccinology. Edible vaccines are an alternative to conventional vaccines, which are typically …

Immunization with the recombinant myosin regulatory light chain (FhrMRLC) in Adjuplex® adjuvant elicits a Th1-biased immune response and a reduction of parasite …

L Buffoni, MM Piva, P Baska, K Januszkiewicz… - Parasitology …, 2020 - Elsevier
The aim of this study was to assess the immune response and the protective efficacy elicited
by the vaccination with the recombinant Fasciola hepatica myosin regulatory light chain …