Late-stage C–H functionalization offers new opportunities in drug discovery

L Guillemard, N Kaplaneris, L Ackermann… - Nature Reviews …, 2021 - nature.com
Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …

C–H activation

T Rogge, N Kaplaneris, N Chatani, J Kim… - Nature Reviews …, 2021 - nature.com
Transition metal-catalysed C–H activation has emerged as an increasingly powerful platform
for molecular syntheses, enabling applications to natural product syntheses, late-stage …

Toward selective oxidation of contaminants in aqueous systems

Z Yang, J Qian, C Shan, H Li, Y Yin… - Environmental Science & …, 2021 - ACS Publications
The presence of diverse pollutants in water has been threating human health and aquatic
ecosystems on a global scale. For more than a century, chemical oxidation using strongly …

Transition metal catalysis controlled by hydrogen bonding in the second coordination sphere

JNH Reek, B de Bruin, S Pullen, TJ Mooibroek… - Chemical …, 2022 - ACS Publications
Transition metal catalysis is of utmost importance for the development of sustainable
processes in academia and industry. The activity and selectivity of metal complexes are …

3d transition metals for C–H activation

P Gandeepan, T Müller, D Zell, G Cera… - Chemical …, 2018 - ACS Publications
C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with
notable applications to material sciences, crop protection, drug discovery, and …

Strategic evolution in transition metal-catalyzed directed C–H bond activation and future directions

S Rej, A Das, N Chatani - Coordination Chemistry Reviews, 2021 - Elsevier
In the field of C–H bond functionalization chemistry, directed C–H bond activation strategies
are highly appreciated due to the high efficiency and selectivity of such reactions towards a …

Electrophotocatalytic oxygenation of multiple adjacent C–H bonds

T Shen, YL Li, KY Ye, TH Lambert - Nature, 2023 - nature.com
Oxygen-containing functional groups are nearly ubiquitous in complex small molecules. The
installation of multiple C–O bonds by the concurrent oxygenation of contiguous C–H bonds …

Achieving site-selectivity for C–H activation processes based on distance and geometry: a carpenter's approach

G Meng, NYS Lam, EL Lucas… - Journal of the …, 2020 - ACS Publications
The ability to differentiate between highly similar C–H bonds in a given molecule remains a
fundamental challenge in organic chemistry. In particular, the lack of sufficient steric and …

New horizons for catalysis disclosed by supramolecular chemistry

G Olivo, G Capocasa, D Del Giudice… - Chemical Society …, 2021 - pubs.rsc.org
The adoption of a supramolecular approach in catalysis promises to address a number of
unmet challenges, ranging from activity (unlocking of novel reaction pathways) to selectivity …

Functional supramolecular systems: Design and applications

IS Antipin, MV Alfimov, VV Arslanov… - Russian Chemical …, 2021 - iopscience.iop.org
The interest in functional supramolecular systems for the design of innovative materials and
technologies, able to fundamentally change the world, is growing at a high pace. The huge …