Cadherin-based adherens junctions (AJs) and desmosomes are crucial to couple
intercellular adhesion to the actin or intermediate filament cytoskeletons, respectively. As …

Desmosomes are intercellular junctions that mediate cell–cell adhesion and anchor the
intermediate filament network to the plasma membrane, providing mechanical resilience to …

To study how cancer cells can withstand fluid shear stress (SS), we isolated SS-resistant
breast and lung cancer cells using a microfluidic circulatory system. These SS-resistant cells …

Desmosomes are cell-cell adhesive organelles with a well-known role in forming strong
intercellular adhesion during embryogenesis and in adult tissues subject to mechanical …

Plakoglobin (also known as?-catenin) is a member of the Armadillo family of proteins and a
paralog of β-catenin. Plakoglobin is a component of both the adherens junctions and …

The Grainyhead-like 1 (GRHL1) transcription factor regulates the expression of desmosomal
cadherin desmoglein 1 (Dsg1) in suprabasal layers of the epidermis. As a consequence, the …

Desmosomes are cell-cell junctions that mediate adhesion and couple the intermediate
filament cytoskeleton to sites of cell-cell contact. This architectural arrangement integrates …

Desmosomes represent adhesive, spot-like intercellular junctions that in association with
intermediate filaments mechanically link neighboring cells and stabilize tissue architecture …

Contacting cells establish different classes of intricate structures at the cell–cell junctions.
These structures are of increasing research interest as they regulate a broad variety of …

Breast cancer recurrence is a major cause of the disease-specific death. Circulating tumor
cells (CTCs) are negatively associated with breast cancer survival. Plakoglobin, a cell …