[HTML][HTML] Actinobacteria in natural products research: Progress and prospects

PA Jose, A Maharshi, B Jha - Microbiological research, 2021 - Elsevier
Actinobacteria are well-recognised biosynthetic factories that produce an extensive
spectrum of secondary metabolites. Recent genomic insights seem to impact the exploitation …

Bioprospecting sponge-associated microbes for antimicrobial compounds

AAG Indraningrat, H Smidt, D Sipkema - Marine drugs, 2016 - mdpi.com
Sponges are the most prolific marine organisms with respect to their arsenal of bioactive
compounds including antimicrobials. However, the majority of these substances are …

Metabolomic tools used in marine natural product drug discovery

KA Stuart, K Welsh, MC Walker… - Expert opinion on drug …, 2020 - Taylor & Francis
Introduction: The marine environment is a very promising resource for natural product
research, with many of these reaching the market as new drugs, especially in the field of …

Molecules to Ecosystems: Actinomycete Natural Products In situ

SW Behie, B Bonet, VM Zacharia, DJ McClung… - Frontiers in …, 2017 - frontiersin.org
Actinomycetes, filamentous actinobacteria found in numerous ecosystems around the globe,
produce a wide range of clinically useful natural products (NP). In natural environments …

A metabolomic approach to target antimalarial metabolites in the Artemisia annua fungal endophytes

HA Alhadrami, AM Sayed, AO El-Gendy, YI Shamikh… - Scientific Reports, 2021 - nature.com
Fungal endophytes are a major source of anti-infective agents and other medically relevant
compounds. However, their classical blinded-chemical investigation is a challenging …

Metabolic profiling and cytotoxic activities of ethanol extract of Dypsis leptocheilos aerial parts and its green synthesized silver nanoparticles supported by network …

MHH Mohammed, ANE Hamed, SF Elhabal… - South African Journal of …, 2023 - Elsevier
Cancer, which is characterized by uncontrolled cell growth and division with loss of
physiological functions. It is one of the most fatal diseases in the world. For thousands of …

Marine Actinobacteria a New Source of Antibacterial Metabolites to Treat Acne Vulgaris Disease—A Systematic Literature Review

MC De La Hoz-Romo, L Díaz, L Villamil - Antibiotics, 2022 - mdpi.com
Acne vulgaris is a multifactorial disease that remains under-explored; up to date it is known
that the bacterium Cutibacterium acnes is involved in the disease occurrence, also …

Anti-cancer and antimicrobial potential of five soil Streptomycetes: a metabolomics-based study

N Osama, W Bakeer, M Raslan… - Royal Society …, 2022 - royalsocietypublishing.org
Lack of new anti-cancer and anti-infective agents directed the pharmaceutical research to
natural products' discovery especially from actinomycetes as one of the major sources of …

Screening marine natural products for new drug leads against trypanosomatids and malaria

M Álvarez-Bardón, Y Pérez-Pertejo, C Ordóñez… - Marine Drugs, 2020 - mdpi.com
Neglected Tropical Diseases (NTD) represent a serious threat to humans, especially for
those living in poor or developing countries. Almost one-sixth of the world population is at …

Marine Actinobacteria as a source of compounds for phytopathogen control: An integrative metabolic-profiling / bioactivity and taxonomical approach

LA Betancur, SJ Naranjo-Gaybor… - PLoS …, 2017 - journals.plos.org
Marine bacteria are considered as promising sources for the discovery of novel biologically
active compounds. In this study, samples of sediment, invertebrate and algae were collected …