Preeclampsia, a pregnancy‐specific syndrome characterized by hypertension, proteinuria
and edema, resolves on delivery of the placenta. Normal pregnancy is itself characterized by …

Aims Preeclampsia is a hypertensive disorder characterized by vascular oxidative stress.
Decreased availability of the vasodilator nitric oxide (NO) has been postulated to be …

Nitric oxide (NO) is a key molecule involved in a variety of biological functions throughout
the whole body. Many studies have been devoted to establish the role of NO in perinatal …

Cationic amino acid transporter 1 (CAT-1) is responsible for the bulk of the uptake of cationic
amino acids in most mammalian cells. Activation of protein kinase C (PKC) leads to down …

Objectives: Hyperuricemia provokes endothelial dysfunction (ECD). Decreased endothelial
nitric oxide synthase (eNOS) activity is an important source of ECD. Cationic amino acid …

Decreased generation of nitric oxide (NO) by endothelial NO synthase (eNOS) characterizes
endothelial dysfunction (ECD). Delivery of arginine to eNOS by cationic amino acid …

Abstract Background/Aims: Vascular endothelial growth factor (VEGF) is an endothelium-
specific peptide that stimulates angiogenesis via two receptor tyrosine kinases, Flt-1 and …

Background: The spectrum of cardiovascular toxicity by cyclosporine (CsA) includes
hypertension, accelerated atherosclerosis, and thrombotic microangiopathy, all of which are …

Endothelial dysfunction because of nitric oxide inactivation has been suggested to play a
role in the pathogenesis of preeclampsia. During pregnancy, L-arginine transport by CAT-1 …

Peroxisome proliferator-activated receptor (PPAR) agonists were shown to inhibit
atherosclerosis through augmentation of endothelial nitric oxide synthase (eNOS) activity. In …