Drugs that are commercially available but have novel mechanisms of action should be
explored as analgesics. This review will discuss haloperidol, miragabalin …

Sigma-1 (σ1) receptor antagonists are promising tools for neuropathic pain treatment, but it
is unknown whether σ1 receptor inhibition ameliorates the neuropathic signs induced by …

The use of haloperidol in pain management has been a topic of interest for several decades.
Haloperidol is a widely used antipsychotic medication with unique pharmacologic properties …

In the majority of patients with breast cancer in the advanced stages, skeletal metastases are
common, which may cause excruciating pain. Currently available drug treatments for relief of …

Despite the availability of multiple therapeutic agents, the search for novel pain
management of neuropathic pain is still a challenge. Oxidative stress and inflammatory …

The efficacy of opioids in the treatment of chronic pain is limited; however, the adverse
effects they produce are considerable. N-palmitoylethanolamide (PEA), a bioactive lipid …

This study evaluates the antiallodynic and antihyperalgesic effects of LMH-2, a new
haloperidol (HAL) analog that acts as sigma-1 receptor (σ1 R) antagonist, in diabetic mice …

Chronic pain is a frequent condition that affects an estimated 20% of people worldwide,
accounting for 15%–20% of doctors' appointments (Treede et al., 2015). It lacks the acute …

Aims Haloperidol is a neuroleptic drug with high affinity towards the σ 1 receptor (σ 1 R),
acting as antagonist that decreases neuropathic pain, but has CNS side effects. This work …

Neuropathic pain is characterized by the presence of hyperalgesia and allodynia.
Pharmacological treatments include the use of antiepileptics such as pregabalin or …