Brain and behavioral evidence for reweighting of vestibular inputs with long-duration spaceflight

KE Hupfeld, HR McGregor, V Koppelmans… - Cerebral …, 2022 - academic.oup.com
Microgravity alters vestibular signaling. In-flight adaptation to altered vestibular afferents is
reflected in post-spaceflight aftereffects, evidenced by declines in vestibularly mediated …

The effects of 30 minutes of artificial gravity on cognitive and sensorimotor performance in a spaceflight analog environment

GD Tays, HR McGregor, JK Lee, N Beltran… - Frontiers in Neural …, 2022 - frontiersin.org
The altered vestibular signaling and somatosensory unloading of microgravity result in
sensory reweighting and adaptation to conflicting sensory inputs. Aftereffects of these …

Changes in working memory brain activity and task-based connectivity after long-duration spaceflight

AP Salazar, HR McGregor, KE Hupfeld… - Cerebral …, 2023 - academic.oup.com
We studied the longitudinal effects of approximately 6 months of spaceflight on brain activity
and task-based connectivity during a spatial working memory (SWM) task. We further …

Cognition in zero gravity: Effects of non-terrestrial gravity on human behaviour

I Arshad, ER Ferré - Quarterly Journal of Experimental …, 2023 - journals.sagepub.com
As humanity prepares for deep space exploration, understanding the impact of spaceflight
on bodily physiology is critical. While the effects of non-terrestrial gravity on the body are …

Neuroplasticity as a foundation for decision-making in space

MB Rappaport, CJ Corbally - NeuroSci, 2022 - mdpi.com
This is an exploratory review of two very recent, intersecting segments of space science:
neuroplasticity in space, and decision-making in space. The high level of neuroplasticity in …

Differential relationships between brain structure and dual task walking in young and older adults

KE Hupfeld, JM Geraghty, HR McGregor… - Frontiers in Aging …, 2022 - frontiersin.org
Almost 25% of all older adults experience difficulty walking. Mobility difficulties for older
adults are more pronounced when they perform a simultaneous cognitive task while walking …

Sensory system-specific associations between brain structure and balance

KE Hupfeld, HR McGregor, CJ Hass, O Pasternak… - Neurobiology of …, 2022 - Elsevier
Nearly 75% of older adults in the US report balance problems. Although it is known that
aging results in widespread brain atrophy, less is known about how brain structure relates to …

Daily artificial gravity partially mitigates vestibular processing changes associated with head-down tilt bedrest

GD Tays, KE Hupfeld, HR McGregor, NE Beltran… - npj …, 2024 - nature.com
Microgravity alters vestibular signaling and reduces body loading, driving sensory
reweighting. The unloading effects can be modelled using head-down tilt bedrest (HDT) …

Daily artificial gravity is associated with greater neural efficiency during sensorimotor adaptation

GD Tays, KE Hupfeld, HR McGregor, NE Beltran… - Cerebral …, 2023 - academic.oup.com
Altered vestibular signaling and body unloading in microgravity results in sensory
reweighting and adaptation. Microgravity effects are well-replicated in head-down tilt bed …

[HTML][HTML] Artificial gravity during a spaceflight analog alters brain sensory connectivity

HR McGregor, JK Lee, ER Mulder, YE De Dios… - NeuroImage, 2023 - Elsevier
Spaceflight has numerous untoward effects on human physiology. Various countermeasures
are under investigation including artificial gravity (AG). Here, we investigated whether AG …