Emergence of extracellular vesicles as “liquid biopsy” for neurological disorders: boom or bust

A Kumar, MA Nader, G Deep, A Baker - Pharmacological reviews, 2024 - Elsevier
Extracellular vesicles (EVs) have emerged as an attractive liquid biopsy approach in the
diagnosis and prognosis of multiple diseases and disorders. The feasibility of enriching …

Exosomes in prostate cancer diagnosis, prognosis and therapy

T Lorenc, K Klimczyk, I Michalczewska… - International Journal of …, 2020 - mdpi.com
Prostate cancer (PCa) is the second most common cause of cancer-related mortality among
men in the developed world. Conventional anti-PCa therapies are not effective for patients …

Exosome proteomic analyses identify inflammatory phenotype and novel biomarkers in African American prostate cancer patients

GK Panigrahi, PP Praharaj, H Kittaka… - Cancer …, 2019 - Wiley Online Library
African American men face a stark prostate cancer (PCa)‐related health disparity, with the
highest incidence and mortality rates compared to other races. Additional and innovative …

Hypoxia-induced exosome secretion promotes survival of African-American and Caucasian prostate cancer cells

GK Panigrahi, PP Praharaj, TC Peak, J Long… - Scientific reports, 2018 - nature.com
African American men in the United States have higher mortality due to prostate cancer
(PCa) compared to other races. One reason for this disparity is the lack of in-depth …

Brain cell-derived exosomes in plasma serve as neurodegeneration biomarkers in male cynomolgus monkeys self-administrating oxycodone

A Kumar, S Kim, Y Su, M Sharma, P Kumar, S Singh… - …, 2021 - thelancet.com
Abstract Background The United States is currently facing an opioid crisis. Novel tools to
better comprehend dynamic molecular changes in the brain associated with the opioid …

The role of cancer stem cell‐derived exosomes in cancer progression

X Li, X Li, B Zhang, B He - Stem Cells International, 2022 - Wiley Online Library
Cancer stem cells (CSCs) represent a small portion of tumor cells with self‐renewal ability in
tumor tissues and are a key factor in tumor resistance, recurrence, and metastasis. CSCs …

A geroscience motivated approach to treat Alzheimer's disease: senolytics move to clinical trials

MM Gonzales, S Krishnamurthy, V Garbarino… - Mechanisms of ageing …, 2021 - Elsevier
The pathogenic processes driving Alzheimer's disease (AD) are complex. An incomplete
understanding of underlying disease mechanisms has presented insurmountable obstacles …

Nanomaterial probes for nuclear imaging

VJX Phua, CT Yang, B Xia, SX Yan, J Liu, SE Aw, T He… - Nanomaterials, 2022 - mdpi.com
Nuclear imaging is a powerful non-invasive imaging technique that is rapidly developing in
medical theranostics. Nuclear imaging requires radiolabeling isotopes for non-invasive …

Regulation of tumor–stroma interactions by the unfolded protein response

J Obacz, T Avril, C Rubio‐Patiño… - The FEBS …, 2019 - Wiley Online Library
The unfolded protein response (UPR) is a conserved adaptive pathway that helps cells cope
with the protein misfolding burden within the endoplasmic reticulum (ER). Imbalance …

[HTML][HTML] Role of extracellular vesicles secretion in paclitaxel resistance of prostate cancer cells

A Kumar, P Kumar, M Sharma, S Kim… - Cancer Drug …, 2022 - ncbi.nlm.nih.gov
Aim: The development of chemotherapy resistance is the major obstacle in the treatment of
advanced prostate cancer (PCa). Extracellular vesicles (EVs) secretion plays a significant …