Deciphering the principles and mechanisms by which gene activity orchestrates complex
cellular arrangements in multicellular organisms has far-reaching implications for research …

Methods for profiling RNA and protein expression in a spatially resolved manner are rapidly
evolving, making it possible to comprehensively characterize cells and tissues in health and …

In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …

The combination of spatial transcriptomics (ST) and single cell RNA sequencing (scRNA-
seq) acts as a pivotal component to bridge the pathological phenomes of human tissues with …

During embryonic development, epithelial cell blocks called somites are periodically formed
according to the segmentation clock, becoming the foundation for the segmental pattern of …

The body plan of the mammalian embryo is shaped through the process of gastrulation, an
early developmental event that transforms an isotropic group of cells into an ensemble of …

Molecular profiling of single cells has advanced our knowledge of the molecular basis of
development. However, current approaches mostly rely on dissociating cells from tissues …

In vitro cell cultures are crucial research tools for modeling human development and
diseases. Although the conventional monolayer cell cultures have been widely used in the …

Building tissues from scratch to explore entirely new cell configurations could revolutionize
fundamental understanding in biology. Bioprinting is an emerging technology to do this …

In recent years considerable progress has been made in the development of faithful
procedures for the differentiation of human pluripotent stem cells (hPSCs). An important step …