Recent advances on social determinants of mental health: looking fast forward
The fields of psychiatry and mental health are increasingly recognizing the importance of
social determinants of health (SDOH) and their impact on mental health outcomes. In this …
social determinants of health (SDOH) and their impact on mental health outcomes. In this …
Trends in big data analyses by multicenter collaborative translational research in psychiatry
The underlying pathologies of psychiatric disorders, which cause substantial personal and
social losses, remain unknown, and their elucidation is an urgent issue. To clarify the core …
social losses, remain unknown, and their elucidation is an urgent issue. To clarify the core …
[HTML][HTML] Polygenic risk scores: An overview from bench to bedside for personalised medicine
B Cross, R Turner, M Pirmohamed - Frontiers in Genetics, 2022 - frontiersin.org
Since the first polygenic risk score (PRS) in 2007, research in this area has progressed
significantly. The increasing number of SNPs that have been identified by large scale GWAS …
significantly. The increasing number of SNPs that have been identified by large scale GWAS …
Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study
IMPACC Manuscript Writing Team… - Science …, 2021 - science.org
The Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) is a prospective
longitudinal study designed to enroll 1000 hospitalized patients with COVID-19 …
longitudinal study designed to enroll 1000 hospitalized patients with COVID-19 …
[HTML][HTML] Systematic comparison of family history and polygenic risk across 24 common diseases
N Mars, JV Lindbohm, P della Briotta Parolo… - The American Journal of …, 2022 - cell.com
Family history is the standard indirect measure of inherited susceptibility in clinical care,
whereas polygenic risk scores (PRSs) have more recently demonstrated potential for more …
whereas polygenic risk scores (PRSs) have more recently demonstrated potential for more …
[HTML][HTML] Changes in early childhood irritability and its association with depressive symptoms and self-harm during adolescence in a nationally representative United …
Objective This study aimed to investigate longitudinal associations between changes in
early childhood irritability, and depressive symptoms and self-harm at 14 years. Method We …
early childhood irritability, and depressive symptoms and self-harm at 14 years. Method We …
[HTML][HTML] Polygenic scores in psychiatry: on the road from discovery to implementation
The hypothesis that multiple genetic variants contribute to psychiatric disorders was first
proposed for schizophrenia in the 1960s, based on epidemiological data (1). This polygenic …
proposed for schizophrenia in the 1960s, based on epidemiological data (1). This polygenic …
[HTML][HTML] Accounting for age of onset and family history improves power in genome-wide association studies
EM Pedersen, E Agerbo, O Plana-Ripoll… - The American Journal of …, 2022 - cell.com
Genome-wide association studies (GWASs) have revolutionized human genetics, allowing
researchers to identify thousands of disease-related genes and possible drug targets …
researchers to identify thousands of disease-related genes and possible drug targets …
[HTML][HTML] Genetic propensity, socioeconomic status, and trajectories of depression over a course of 14 years in older adults
Depression is one of the leading causes of disability worldwide and is a major contributor to
the global burden of disease among older adults. The study aimed to investigate the …
the global burden of disease among older adults. The study aimed to investigate the …
The relationship between genotype-and phenotype-based estimates of genetic liability to human psychiatric disorders, in practice and in theory
Genetics as a science has roots in studying phenotypes of relatives, but molecular
approaches facilitate direct measurements of genomic variation within individuals …
approaches facilitate direct measurements of genomic variation within individuals …