Tissue engineering has produced innovative tools for cancer research. 3D cancer models
based on molecularly designed biomaterials aim to harness the dimensionality and …

Cancer progression is associated with extensive remodeling of the tumor microenvironment
(TME), resulting in alterations of biochemical and biophysical cues that affect both cancer …

During metastasis, disseminated tumor cells (DTCs) from the primary tumor infiltrate
secondary organs and reside there for varying lengths of time prior to forming new tumors …

Collagen is the most abundant protein in mammals, accounting for approximately one-third
of the total protein in the human body. Thus, it is a logical choice for the creation of …

Late recurrences of breast cancer are hypothesized to arise from disseminated tumor cells
(DTCs) that reactivate after dormancy and occur most frequently with estrogen receptor …

Active targeting of tumors is believed to be the key to efficient cancer therapy and accurate,
early-stage diagnostics. Active targeting implies minimized off-targeting and associated …

Three-dimensional (3D) printing, also known as additive manufacturing, was first introduced
in 1986. 1 Unlike the techniques that can only be used for mass-produced goods in classical …

Engineered hydrogels are increasingly used as extracellular matrix (ECM) surrogates for
probing cell function in response to ECM remodeling events related to injury or disease (eg …

Clinical evidence supports a role for the extracellular matrix (ECM) in cancer risk and
prognosis across multiple tumor types, and numerous studies have demonstrated that …

Extracellular matrix (ECM) stiffening is a common occurrence during the progression of
many diseases, such as breast cancer. To accurately mimic the pathophysiological context …