[HTML][HTML] All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases

A Fasano - F1000Research, 2020 - ncbi.nlm.nih.gov
Improved hygiene leading to reduced exposure to microorganisms has been implicated as
one possible cause for the recent “epidemic” of chronic inflammatory diseases (CIDs) in …

[HTML][HTML] The structure and function of the human small intestinal microbiota: current understanding and future directions

AJ Kastl Jr, NA Terry, GD Wu, LG Albenberg - Cellular and molecular …, 2020 - Elsevier
Despite growing literature characterizing the fecal microbiome and its association with
health and disease, few studies have analyzed the microbiome of the small intestine. Here …

Severe childhood malnutrition

ZA Bhutta, JA Berkley, RHJ Bandsma… - Nature reviews Disease …, 2017 - nature.com
The main forms of childhood malnutrition occur predominantly in children< 5 years of age
living in low-income and middle-income countries and include stunting, wasting and …

Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or …

BR Stevens, R Goel, K Seungbum, EM Richards… - Gut, 2018 - gut.bmj.com
We read with interest the recent work by Uhde et al, 1 which demonstrated that physically
asymptomatic non-coeliac gluten/wheat sensitivity involves compromised intestinal …

Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases

C Sturgeon, A Fasano - Tissue barriers, 2016 - Taylor & Francis
Beside digesting nutrients and absorbing solutes and electrolytes, the intestinal epithelium
with its barrier function is in charge of a tightly controlled antigen trafficking from the …

Impact of childhood malnutrition on host defense and infection

MK Ibrahim, M Zambruni, CL Melby… - Clinical microbiology …, 2017 - Am Soc Microbiol
The global impact of childhood malnutrition is staggering. The synergism between
malnutrition and infection contributes substantially to childhood morbidity and mortality …

Environmental enteric dysfunction pathways and child stunting: A systematic review

KM Harper, M Mutasa, AJ Prendergast… - PLoS neglected …, 2018 - journals.plos.org
Background Environmental enteric dysfunction (EED) is commonly defined as an acquired
subclinical disorder of the small intestine, characterized by villous atrophy and crypt …

Prevotella copri and microbiota members mediate the beneficial effects of a therapeutic food for malnutrition

HW Chang, EM Lee, Y Wang, C Zhou, KM Pruss… - Nature …, 2024 - nature.com
Microbiota-directed complementary food (MDCF) formulations have been designed to repair
the gut communities of malnourished children. A randomized controlled trial demonstrated …

Campylobacter vaccination reduces diarrheal disease and infant growth stunting among rhesus macaques

SM Hendrickson, A Thomas, HP Raué… - Nature …, 2023 - nature.com
Campylobacter-associated enteric disease is estimated to be responsible for more than 160
million cases of gastroenteritis each year and is linked to growth stunting of infants living …

Sanitation facilities, hygienic conditions, and prevalence of acute diarrhea among under-five children in slums of Addis Ababa, Ethiopia: baseline survey of a …

M Adane, B Mengistie, H Kloos, G Medhin, W Mulat - PloS one, 2017 - journals.plos.org
Background In developing countries, children under the age of five years who live in slums
are highly vulnerable to diarrhea. However, there is a paucity of information on the …