Phenotypic and functional heterogeneity is one of the hallmarks of human cancers. Tumor
genotype variations among tumors within different patients are known as interpatient …

Gastric cancer is a leading cause of cancer death worldwide. Diet, obesity, smoking and
chronic infections, especially with Helicobacter pylori, contribute to stomach cancer …

Abstract Cys2-His2 zinc finger (C2H2-ZF) proteins represent the largest class of putative
human transcription factors. However, for most C2H2-ZF proteins it is unknown whether they …

Epigenetic alterations in the cancer methylome are common in breast cancer and provide
novel options for tumour stratification. Here, we perform whole-genome methylation capture …

Zinc finger proteins containing the Kruppel associated box (KRAB-ZFPs) constitute the
largest individual family of transcriptional repressors encoded by the genomes of higher …

This study investigates aberrant DNA methylations as potential diagnosis and prognosis
markers for esophageal squamous-cell carcinoma (ESCC), which if diagnosed at advanced …

Signal transducer and activator of transcription 3 (STAT3) is a central regulator of immune
homeostasis. STAT3 levels are strictly controlled, and STAT3 impairment contributes to …

Krüppel-associated box zinc finger proteins (KRAB-ZFPs) constitute the largest family of
transcriptional factors exerting co-repressor functions in mammalian cells. In general, KRAB …

Esophageal cancer is one of the most common malignancies in the world. Squamous cell
carcinoma accounts for approximately 90% of esophageal cancer cases. Genetic and …

Kruppel-associated box (KRAB) zinc-finger proteins (KRAB-ZFPs) are the largest
transcriptional/transcription-regulatory factor family in mammalian cells. The amino-terminal …