Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear
receptor family whose expression and activities are restricted to a limited number of organs …

Hepatocyte nuclear factor 4 alpha (HNF4α) is a multi-faceted nuclear receptor responsible
for governing the development and proper functioning of liver and pancreatic islet cells. Its …

Abstract HNF4A and HNF1A encode transcription factors that are important for the
development and function of the pancreas and liver. Mutations in both genes have been …

Transcription modulated by the circadian clock is diverse across cell types, underlying
circadian control of peripheral metabolism and its observed perturbation in human diseases …

Abstract Background and Aims Hepatocyte nuclear factor 4 alpha (HNF4α) is indispensable
for hepatocyte differentiation and critical for maintaining liver health. Here, we demonstrate …

Ribosomes are often seen as monolithic machines produced from uniformly regulated
genes. However, in yeast most ribosomal proteins come from duplicated genes. Here, we …

In sepsis, limited food intake and increased energy expenditure induce a starvation
response, which is compromised by a quick decline in the expression of hepatic PPARα, a …

Background & Aims Our understanding of the interactions between HBV and its host cells is
still quite limited. Spliceosome associated factor 1 (SART1) has recently been found to …

In 1998 the fetal insulin hypothesis proposed that lower birthweight and adult-onset type 2
diabetes are two phenotypes of the same genotype. Since then, advances in research …

Renal osteodystrophy (ROD) is a disorder of bone metabolism that affects virtually all
patients with chronic kidney disease (CKD) and is associated with adverse clinical outcomes …