Large-scale cancer genomics, proteomics and RNA-sequencing efforts are currently
mapping in fine detail the genetic and biochemical alterations that occur in cancer. However …

Fractal characteristics of chromatin, revealed by light or electron microscopy, have been
reported during the last 20 years. Fractal features can easily be estimated in digitalized …

To investigate the transition from non-cancerous to metastatic from a physical sciences
perspective, the Physical Sciences–Oncology Centers (PS-OC) Network performed …

Normal cell function is dependent on the proper maintenance of chromatin structure.
Regulation of chromatin structure is controlled by histone modifications that directly …

Chemical fixation is nearly indispensable in the biological sciences, especially in
circumstances where cryo-fixation is not applicable. While universally employed for the …

Most of what we know about gene transcription comes from the view of cells as molecular
machines: focusing on the role of molecular modifications to the proteins carrying out …

Quantitative phase imaging (QPI), a method that precisely recovers the wavefront of an
electromagnetic field scattered by a transparent, weakly scattering object, is a rapidly …

The organization of chromatin is a regulator of molecular processes including transcription,
replication, and DNA repair. The structures within chromatin that regulate these processes …

Light scattering has become a common biomedical research tool, enabling diagnostic
sensitivity to myriad tissue alterations associated with disease. Light–tissue interactions are …

The spatial architecture and dynamics of the genomic material in the limited volume of the
nucleus plays an important role in biological processes ranging from gene expression to …