[HTML][HTML] Unveiling the anti-cancer mechanisms of calotropin: Insights into cell growth inhibition, cell cycle arrest, and metabolic regulation in human oral squamous …

S Jayaraman, SR Natarajan, VP Veeraraghavan… - Journal of Oral Biology …, 2023 - Elsevier
Background Calotropin, a cardiac glycoside obtained from the plant Calotropis gigantea,
has demonstrated promising potential as an anti-tumorigenesis compound. Objective The …

Combination of ethyl acetate fraction from Calotropis gigantea stem bark and sorafenib induces apoptosis in HepG2 cells

P Chaisupasakul, D Pekthong, A Wangteeraprasert… - Plos one, 2024 - journals.plos.org
The cytotoxicity of the ethyl acetate fraction of the Calotropis gigantea (L.) Dryand.(C.
gigantea) stem bark extract (CGEtOAc) has been demonstrated in many types of cancers …

The dichloromethane fraction from Calotropis gigantea (L.) dryand. Stem bark extract prevents liver cancer in SDT rats with insulin-independent diabetes mellitus

T Haewphet, S Parhira, P Chaisupasakul… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Calotropis gigantea (L.) Dryand.(C. gigantea) is a
traditional medicinal plant, recognized for its effectiveness in managing diabetes, along with …

Calotropis procera: A double edged sword against glioblastoma, inhibiting glioblastoma cell line growth by targeting histone deacetylases (HDAC) and angiogenesis

SHS Alanazi, MF Khan, AM Alazami, A Baabbad… - Heliyon, 2024 - cell.com
Despite substantial investments in anti-glioblastoma (GBM) drug discovery over the last
decade, progress is limited to preclinical stages, with clinical studies frequently encountering …

[HTML][HTML] An Overview on the Phytochemical and Therapeutic potential of Calotropis procera

NK Singh, B Bhushan, Y Agrahari - Pharmacological Research-Modern …, 2024 - Elsevier
INTRODUCTION Various natural phytomedicines originating from Chinese herbs exhibit
numerous pharmacological activities. Calotropis procera (CP), communally known as Aak, is …

[HTML][HTML] The Volatile Compounds Composition of Different Parts of Wild Kazakhstan Sedum ewersii Ledeb.

T Kobylina, A Novikov, G Sadyrova, E Kyrbassova… - Separations, 2024 - mdpi.com
The chemical composition of Sedum ewersii Ledeb., a plant indigenous to Kazakhstan and
traditionally utilized in folk medicine, was comprehensively investigated, with a focus on its …

[HTML][HTML] Calotropin attenuates ischemic heart failure after myocardial infarction by modulating SIRT1/FOXD3/SERCA2a pathway

Z Chen, H Yao, X Yao, R Zheng, Y Yang, Z Liu… - Biomedicine & …, 2024 - Elsevier
Heart failure (HF) represents the terminal stage of cardiovascular diseases, with limited
therapeutic options currently available. Calotropin (CAL), a cardenolide isolated from …

Calotropis gigantea: An in-depth review of its therapeutic potential

A Dwivedi, S Pratap, S Awasthi… - Journal of …, 2024 - phytojournal.com
Background: Calotropis gigantea, belonging to the Asclepiadaceae family, is a perennial
herb in question that has been used in the field of traditional medicine for an extensive …

Calotropin: Natural Phytomolecules for Cutting-edge Features

S Nag, R Paul, S Mondal, N Panigrahi… - Pharmacognosy …, 2023 - phcogres.com
Phytochemical is a collective term for plant chemicals with varied structure and function. The
most common sources of phytochemicals are fruits, vegetables, whole grains, nuts and …

Selective cytotoxicity and anticancer activity: ROS-induced cell death facilitated by metal complex

H Sato, M Doskali, Z Balmaganbet… - BIO Web of …, 2024 - bio-conferences.org
Hepatocellular carcinoma (HCC) recurrence rate consists of 10%-20% and remains the
leading cause of cancer-related death. We have successfully designed the protocol for …