BACKGROUND: With increasing evidence that hydroperoxides are not only toxic but rather
exert essential physiological functions, also hydroperoxide removing enzymes have to be re …

Mammalian cells possess a multifaceted antioxidant enzyme system, which includes
superoxide dismutases, catalase, the peroxiredoxin/thioredoxin and the glutathione …

Selenium (Se) is an essential micronutrient that has several important functions in animal
and human health. The biological functions of Se are carried out by selenoproteins …

Glutathione peroxidases are well known antioxidant enzymes. They catalyze the reduction
of hydrogen peroxide or organic hydroperoxides using glutathione. Among the reported 8 …

The discovery of multiple selenoproteins has raised tantalizing questions about their role in
maintaining normal cellular function. Unfortunately, many of these remain inadequately …

Selenium (Se) is an essential micronutrient for humans, acting as a component of the
unusual amino acids, selenocysteine (Se-Cys) and selenomethionine (Se-Met). Where Se …

Oxidative stress is a disturbance in the equilibrium among free radicals, reactive oxygen
species, and endogenous antioxidant defense mechanisms. Oxidative stress is a result of …

Living organisms use selenium mainly in the form of selenocysteine in the active site of
oxidoreductases. Here, selenium's unique chemistry is believed to modulate the reaction …

Selenium is a micronutrient essential to human health and has long been associated with
cancer prevention. Functionally, these effects are thought to be mediated by a class of …

Maintenance of cellular redox control is pivotal for normal cellular functions and cell fate
decisions including cell death. Among the key cellular redox systems in mammals, the …