New discoveries providing insights into mitochondrial bioenergetics, their dynamic
interactions as well as their role in cellular homeostasis have dramatically advanced our …

Parkinson's disease is a common, progressive neurodegenerative disorder, affecting 3% of
those older than 75 years of age. Clinically, Parkinson's disease (PD) is associated with …

Abstract Calcium (Ca 2+) is a ubiquitous second messenger that regulates various activities
in eukaryotic cells. Especially important role calcium plays in excitable cells. Neurons …

Parkinson's disease (PD) is the second most common neurodegenerative disease in the
world. Its causes are poorly understood and there is no proven therapeutic strategy for …

Across all kingdoms in the tree of life, calcium (Ca2+) is an essential element used by cells
to respond and adapt to constantly changing environments. In multicellular organisms, it …

Objective To determine the extent of respiratory chain abnormalities and investigate the
contribution of mtDNA to the loss of respiratory chain complexes (CI–IV) in the substantia …

Parkinson's disease is the second most common neurodegenerative movement disorder;
however, its etiology remains elusive. Nevertheless, in vivo observations have concluded …

Parkinson's disease is one of the most common neurodegenerative disorders worldwide,
characterized by a progressive loss of dopaminergic neurons mainly localized in the …

Genetic testing for persons with Parkinson's disease is becoming increasingly common.
Significant gains have been made regarding genetic testing methods, and testing is …

Parkinson disease (PD) is a complex neurodegenerative disorder, usually with multifactorial
etiology. It is characterized by prominent movement disorders and non-motor symptoms …