Ubc13-catalyzed K63 ubiquitination is a major control point for immune signaling. Recent
evidence has shown that the control of multiple immune functions, including chronic …

The interferon regulatory factor (IRF) family of transcription factors play a vital role in the
human innate antiviral immune responses with production of interferons (IFNs) as a hallmark …

Background Neuroinflammation-induced injury is intimately associated with poor prognosis
in patients with cerebral venous sinus thrombosis (CVST). The cyclic GMP-AMP synthase …

Stimulator of interferon genes (STING) is an endoplasmic-reticulum resident protein, playing
essential roles in immune responses against microbial infections. However, over-activation …

Endothelial dysfunction develops gradually with age, and is the foundation of many age-
related diseases in the elderly. The purpose of this study was to investigate the role of the …

The efficacious detection of pathogens and prompt induction of innate immune signaling
serve as a crucial component of immune defense against infectious pathogens. Over the …

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling
pathway serves as a pivotal mediator of innate immunity by triggering the secretion of type I …

Alleviating odontoblast inflammation is crucial to control the progression of pulpitis.
Mitochondrial DNA (mtDNA) is a vital driver of inflammation when it leaks from mitochondria …

Since cyclic guanosine monophosphate‐adenosine monophosphate synthase (cGAS)–
stimulator of interferon genes (STING) signaling pathway was discovered in 2013, great …

Membrane-associated RING-CH-type finger (MARCH) proteins have been reported to
regulate type I IFN production during host antiviral innate immunity. The present study …