Mitochondrial diseases are extremely heterogeneous genetic conditions characterized by
faulty oxidative phosphorylation (OXPHOS). OXPHOS deficiency can be the result of …

Summary Background Mitochondrial DNA (mtDNA) encodes 37 genes necessary for
synthesizing 13 essential subunits of the oxidative phosphorylation system. mtDNA …

Mitochondrial diseases are a heterogeneous group of diseases resulting from energy deficit
and reduced adenosine triphosphate (ATP) production due to impaired oxidative …

Preclinical work aimed at developing new therapies for mitochondrial diseases has recently
given new hopes and opened unexpected perspectives for the patients affected by these …

Introduction: Mitochondrial disease is a spectrum of debilitating disorders caused by
mutations in the mitochondrial DNA (mtDNA) or nuclear DNA that compromises the …

The landmark year 1988 can be considered as the birthdate of mitochondrial medicine,
when the first pathogenic mutations affecting mtDNA were associated with human diseases …

(1) Background: The development of mitochondrial medicine has been severely impeded by
a lack of effective therapies.(2) Methods: To better understand Mitochondrial …

Circulating metabolites are indicators of systemic metabolic dysfunction and can be detected
through contemporary techniques in metabolomics. These metabolites are involved in …

Background The vision loss in Leber hereditary optic neuropathy patients is due to
mitochondrial DNA mutations. No treatment has shown a clear-cut benefit on a clinically …

Purpose: Both aging and neurodegenerative illnesses are thought to be influenced by
mitochondrial malfunction and free radical formation. Deformities of the energy metabolism …