Medial Arterial Calcification: JACC State-of-the-Art Review

P Lanzer, FM Hannan, JD Lanzer, J Janzen… - Journal of the American …, 2021 - jacc.org
Medial arterial calcification (MAC) is a chronic systemic vascular disorder distinct from
atherosclerosis that is frequently but not always associated with diabetes mellitus, chronic …

Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness

AL Durham, MY Speer, M Scatena… - Cardiovascular …, 2018 - academic.oup.com
Vascular calcification is associated with a significant increase in all-cause mortality and
atherosclerotic plaque rupture. Calcification has been determined to be an active process …

Role of vascular smooth muscle cell phenotypic switching and calcification in aortic aneurysm formation: involvement of vitamin K-dependent processes

P Petsophonsakul, M Furmanik, R Forsythe… - … , and vascular biology, 2019 - Am Heart Assoc
Aortic aneurysm is a vascular disease whereby the ECM (extracellular matrix) of a blood
vessel degenerates, leading to dilation and eventually vessel wall rupture. Recently, it was …

Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells

T Hadi, L Boytard, M Silvestro, D Alebrahim… - Nature …, 2018 - nature.com
Abdominal aortic aneurysms (AAA) are characterized by extensive extracellular matrix
(ECM) fragmentation and inflammation. However, the mechanisms by which these events …

Inherited thoracic aortic disease: new insights and translational targets

AJ Fletcher, MBJ Syed, TJ Aitman, DE Newby… - Circulation, 2020 - Am Heart Assoc
Inherited thoracic aortopathies denote a group of congenital conditions that predispose to
disease of the thoracic aorta. Aortic wall weakness and abnormal aortic hemodynamic …

Altered vascular extracellular matrix in the pathogenesis of atherosclerosis

R Mohindra, DK Agrawal, FG Thankam - Journal of cardiovascular …, 2021 - Springer
Cardiovascular disease continues to grow as a massive global health burden, with coronary
artery disease being one of its most lethal varieties. The pathogenesis of atherosclerosis …

Endothelial dysfunction in Marfan syndrome mice is restored by resveratrol

A Mieremet, M van der Stoel, S Li, E Coskun… - Scientific reports, 2022 - nature.com
Patients with Marfan syndrome (MFS) develop thoracic aortic aneurysms as the aorta
presents excessive elastin breaks, fibrosis, and vascular smooth muscle cell (vSMC) death …

Cell-matrix interactions and matricrine signaling in the pathogenesis of vascular calcification

D Ngai, M Lino, MP Bendeck - Frontiers in cardiovascular medicine, 2018 - frontiersin.org
Vascular calcification is a complex pathological process occurring in patients with
atherosclerosis, type 2 diabetes, and chronic kidney disease. The extracellular matrix, via …

Unveiling cellular and molecular aspects of ascending thoracic aortic aneurysms and dissections

BH Ganizada, RJA Veltrop, AC Akbulut… - Basic Research in …, 2024 - Springer
Ascending thoracic aortic aneurysm (ATAA) remains a significant medical concern, with its
asymptomatic nature posing diagnostic and monitoring challenges, thereby increasing the …

The biology of vascular calcification

D Quaglino, F Boraldi, FD Lofaro - … review of cell and molecular biology, 2020 - Elsevier
Vascular calcification (VC), characterized by different mineral deposits (ie, carbonate apatite,
whitlockite and hydroxyapatite) accumulating in blood vessels and valves, represents a …