Wound healing requires cooperation between different cell types, among which
macrophages play a central role. In particular, inflammatory macrophages are engaged in …

Amino acid metabolism is a critical regulator of the immune response, and its modulating
becomes a promising approach in various forms of immunotherapy. Insufficient …

Abstract N6-methyladenosine (m6A) is a reversible mRNA modification that has been shown
to play important roles in various biological processes. However, the roles of m6A …

A growing body of evidence indicates that, over the course of evolution of the immune
system, arginine has been selected as a node for the regulation of immune responses. An …

Macrophage activation is intimately linked to metabolic reprogramming. Inflammatory (M1)
macrophages are able to sustain inflammatory responses and to kill pathogens, mostly by …

Macrophage polarization refers to how macrophages have been activated at a given point in
space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate …

Classically (M1) and alternatively activated (M2) macrophages exhibit distinct phenotypes
and functions. It has been difficult to dissect macrophage phenotypes in vivo, where a …

Microglia are critical nervous system‐specific immune cells serving as tissue‐resident
macrophages influencing brain development, maintenance of the neural environment …

Background Myeloid cells are an abundant leukocyte in many types of tumors and contribute
to immune evasion. Expression of the enzyme arginase 1 (Arg1) is a defining feature of …

The healing of cutaneous wounds is dependent on the progression through distinct, yet
overlapping phases of wound healing, including hemostasis, inflammation, proliferation, and …