The cardiac ryanodine receptor (RyR2) is an intracellular Ca 2+ release channel vital for the
function of the heart. Physiologically, RyR2 is triggered to release Ca 2+ from the …

BACKGROUND: Transverse (t)-tubules drive the rapid and synchronous Ca2+ rise in
cardiac myocytes. The virtual complete atrial t-tubule loss in heart failure (HF) decreases …

Abstract Dynamin‐related protein 1 (Drp1) is a cytosolic GTPase protein that when activated
translocates to the mitochondria, meditating mitochondrial fission and increasing reactive …

The coordinated release of Ca 2+ from the sarcoplasmic reticulum (SR) is critical for
excitation-contraction coupling. This release is facilitated by ryanodine receptors (RyRs) that …

Heart failure with preserved ejection fraction (HFpEF) constitutes more than half of all HF
cases, yet evidence-based therapies remain lacking due to limited understanding of its …

During exercise or stress, the sympathetic system stimulates cardiac contractility via β‐
adrenergic receptor (β‐AR) activation, resulting in phosphorylation of the cardiac ryanodine …

Introduction: Hypertrophies of the cardiac septum are caused either by aortic valve stenosis
(AVS) or by congenital hypertrophic obstructive cardiomyopathy (HOCM). As they induce …

Introduction: Heterozygous autosomal-dominant single nucleotide variants in RYR2 account
for 60% of cases of catecholaminergic polymorphic ventricular tachycardia (CPVT), an …

The type 2 ryanodine receptor (RyR2) is the major Ca 2+ release channel required for Ca 2+-
induced Ca 2+ release (CICR) and cardiac excitation-contraction coupling. The cluster …

Background: Ryanodine receptor 2 (RyR2) is one of the first substrates undergoing
phosphorylation upon catecholaminergic stimulation. Yet, the role of RyR2 phosphorylation …