Microbiota can significantly contribute to colorectal cancer initiation and development. It was
described that E. coli harbouring polyketide synthase (pks) genes can synthetize bacterial …

Covering: up to 2021 Colibactin (s), a group of secondary metabolites produced by the pks
island (clb cluster) of Escherichia coli, shows genotoxicity relevant to colorectal cancer and …

The relative contribution of diet to colorectal cancer (CRC) incidence is higher than that for
other cancers. Animal models have revealed that Escherichia coli containing polyketide …

Abstract Background The Escherichia coli strain that is known to produce the genotoxic
secondary metabolite colibactin is linked to colorectal oncogenesis. Therefore …

Colibactin is a polyketide-nonribosomal peptide hybrid secondary metabolite that can form
interstrand cross-links in double-stranded DNA. Colibactin-producing Escherichia coli has …

Escherichia coli containing polyketide synthase in the gut microbiota (pks+ E coli) produce a
polyketide‐peptide genotoxin, colibactin, and are suspected to play a role in the …

There has been increasing evidence that a local inflammatory response stimulates tumor
cells to acquire metastatic potential, and the concept of inflammatory oncotaxis has been …

We investigated the relationship between colibactin-producing (clb+) Escherichia coli and
colorectal adenocarcinoma. In total, 729 E. coli colonies were isolated from tumor and …

The human microbiota produces molecules that are evolved to interact with the diverse
cellular machinery of both the host and microbes, mediating health and diseases. One of the …

Bacteria protect themselves from the toxicity of antimicrobial metabolites they produce
through several strategies. In one resistance mechanism, bacteria assemble a non-toxic …