BACKGROUND Oocyte aging has significant clinical consequences, and yet no treatment
exists to address the age-related decline in oocyte quality. The lack of progress in the …

The female reproductive system is of great significance to women's health. Aging of the
female reproductive system occurs approximately 10 years prior to the natural age …

PURPOSE To determine whether germline BRCA (g BRCA) pathogenic variants are
associated with decreased ovarian reserve. MATERIALS AND METHODS An individual …

Circular RNAs (circRNAs) are covalently closed structural isoforms of linear mRNA which
have been observed across a broad range of species and tissues. Here, we provide a …

Female fertility and offspring health are critically dependent on the maintenance of an
adequate supply of high-quality oocytes. Like somatic cells, oocytes are subject to a variety …

Women are born with all of their oocytes. The oocyte proteome must be maintained with
minimal damage throughout the woman's reproductive life, and hence for decades. Here we …

Ageing is a multi-factorial phenomenon which is considered as a major risk factor for the
development of neurodegeneration, osteoporosis, cardiovascular disease, dementia …

Individualized ovarian stimulation approaches combined with improvements in
cryopreservation techniques increased the success and safety margin to preserve fertility …

The biological function of human ovaries declines along with aging. To identify the
underlying molecular changes during ovarian aging, pigs were used as model animals …

Women with advanced maternal age exhibit low anti-Müllerian hormone (AMH) levels and
an altered follicular environment, which is associated with poor oocyte quality and …