[HTML][HTML] Polymer-and lipid-based nanocarriers for ocular drug delivery: current status and future perspectives

H Han, S Li, M Xu, Y Zhong, W Fan, J Xu, T Zhou… - Advanced Drug Delivery …, 2023 - Elsevier
Ocular diseases seriously affect patients' vision and life quality, with a global morbidity of
over 43 million blindness. However, efficient drug delivery to treat ocular diseases …

Recent advances in age-related macular degeneration therapies

M Fabre, L Mateo, D Lamaa, S Baillif, G Pagès… - Molecules, 2022 - mdpi.com
Age-related macular degeneration (AMD) was described for the first time in the 1840s and is
currently the leading cause of blindness for patients over 65 years in Western Countries …

Nanoparticles in ocular applications and their potential toxicity

C Yang, J Yang, A Lu, J Gong, Y Yang, X Lin… - Frontiers in molecular …, 2022 - frontiersin.org
Nanotechnology has been developed rapidly in recent decades and widely applied in
ocular disease therapy. Nano-drug delivery systems overcome the bottlenecks of current …

Absorption enhancement strategies in chitosan-based nanosystems and hydrogels intended for ocular delivery: Latest advances for optimization of drug permeation

I Dmour - Carbohydrate Polymers, 2024 - Elsevier
Ophthalmic diseases can be presented as acute diseases like allergies, ocular infections,
etc., or chronic ones that can be manifested as a result of systemic disorders, like diabetes …

Optimization of an injectable hydrogel depot system for the controlled release of retinal-targeted hybrid nanoparticles

I Ottonelli, A Bighinati, E Adani, F Loll, R Caraffi… - Pharmaceutics, 2022 - mdpi.com
A drawback in the development of treatments that can reach the retina is the presence of
barriers in the eye that restrain compounds from reaching the target. Intravitreal injections …

Recent advances of ocular drug delivery systems: prominence of ocular implants for chronic eye diseases

M Mostafa, A Al Fatease, RG Alany, H Abdelkader - Pharmaceutics, 2023 - mdpi.com
Chronic ocular diseases can seriously impact the eyes and could potentially result in
blindness or serious vision loss. According to the most recent data from the WHO, there are …

Therapeutic approaches for age-related macular degeneration

RM Galindo-Camacho, C Blanco-Llamero… - International journal of …, 2022 - mdpi.com
Damage to the retinal pigment epithelium, Bruch's membrane and/or tissues underlying
macula is known to increase the risk of age-related macular degeneration (AMD). AMD is …

The idiosyncratic efficacy of spironolactone-loaded PLGA nanoparticles against murine intestinal schistosomiasis

WE Abd El Hady, GA El-Emam, NE Saleh… - International Journal …, 2023 - Taylor & Francis
Background Schistosomiasis is a chronic debilitating parasitic disease accompanied with
severe mortality rates. Although praziquantel (PZQ) acts as the sole drug for the …

Sirolimus loaded chitosan functionalized PLGA nanoparticles protect against sodium iodate-induced retinal degeneration

R Suri, TC Nag, N Mehra, YR Neupane, S Shafi… - Journal of Drug Delivery …, 2023 - Elsevier
Age-related macular degeneration (AMD) is a major health concern in the ageing human
population. Though existing therapeutics have shown some efficacy, low retinal …

[HTML][HTML] Age-Related Macular Degeneration (AMD): Pathophysiology, Drug Targeting Approaches, and Recent Developments in Nanotherapeutics

M Singh, R Negi, Alka, R Vinayagam, SG Kang… - Medicina, 2024 - mdpi.com
The most prevalent reason for vision impairment in aging inhabitants is age-related macular
degeneration (AMD), a posterior ocular disease with a poor understanding of the anatomic …