Precursor messenger RNA (pre-mRNA) splicing is an essential step in the flow of
information from DNA to protein in all eukaryotes. Research over the past four decades has …

Pre-messenger RNA (pre-mRNA) splicing is a central step in gene expression. Lying
between transcription and protein synthesis, pre-mRNA splicing removes sequences …

Mechanistic understanding of pre-mRNA splicing requires detailed structural information on
various states of the spliceosome. Here we report the cryo electron microscopy (cryo-EM) …

Splicing of precursor messenger RNA (pre-mRNA) in yeast is executed by the spliceosome,
which consists of five small nuclear ribonucleoproteins (snRNPs), NTC (nineteen complex) …

Abstract U4/U6. U5 tri-snRNP is a 1.5-megadalton pre-assembled spliceosomal complex
comprising U5 small nuclear RNA (snRNA), extensively base-paired U4/U6 snRNAs and …

Splicing of precursor messenger RNA is performed by the spliceosome. In the cryogenic
electron microscopy structure of the yeast spliceosome, U5 small nuclear ribonucleoprotein …

The active centre of the spliceosome consists of an intricate network formed by U5, U2 and
U6 small nuclear RNAs, and a pre-messenger-RNA substrate. Prp8, a component of the U5 …

Retinitis pigmentosa (RP) is a genetically heterogeneous disorder characterized by
progressive degeneration of the peripheral retina leading to night blindness and loss of …

Mammalian U2AF65 and UAP56 are required for prespliceosome (PS) formation. We tested
the predictions that the yeast UAP56 homolog, SUB2, is required for the same step and …

Ceramides and sphingoid long-chain bases (LCBs) are precursors to more complex
sphingolipids and play distinct signaling roles crucial for cell growth and survival. Conserved …