Foot ulcers are one of the most common and severe complication of diabetes mellitus with
significant resultant morbidity and mortality. Multiple factors impair wound healing include …

This review takes an inclusive approach to microvascular dysfunction in diabetes mellitus
and cardiometabolic disease. In virtually every organ, dynamic interactions between the …

Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …

Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …

Quantitative sensory testing (QST) is a psychophysical method used to quantify
somatosensory function in response to controlled stimuli in healthy subjects and patients …

The free radical theory of aging proposes that reactive oxygen species (ROS)-induced
accumulation of damage to cellular macromolecules is a primary driving force of aging and a …

Diabetic polyneuropathy (DPN) is defined as peripheral nerve dysfunction. There are three
main alterations involved in the pathologic changes of DPN: inflammation, oxidative stress …

Objective To develop a scientifically sound and clinically relevant evidence-based guideline
for the treatment of painful diabetic neuropathy (PDN). Methods We performed a systematic …

Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging
supplements, and even pet food. It is well-defined as a therapy for preventing diabetic …