Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases
Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …
Epidermal growth factor receptor (EGFR) signaling in cancer
N Normanno, A De Luca, C Bianco, L Strizzi… - Gene, 2006 - Elsevier
The epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine
kinases (RTK). These trans-membrane proteins are activated following binding with peptide …
kinases (RTK). These trans-membrane proteins are activated following binding with peptide …
Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling
Although inflammation plays critical roles in the development of atherosclerosis, its
regulatory mechanisms remain incompletely understood. Perivascular adipose tissue …
regulatory mechanisms remain incompletely understood. Perivascular adipose tissue …
The brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis
Brown fat activates uncoupled respiration in response to cold temperature and contributes to
systemic metabolic homeostasis. To date, the metabolic action of brown fat has been …
systemic metabolic homeostasis. To date, the metabolic action of brown fat has been …
[HTML][HTML] The ErbB signaling network: receptor heterodimerization in development and cancer
MA Olayioye, RM Neve, HA Lane, NE Hynes - The EMBO journal, 2000 - embopress.org
Cells are continuously exposed to diverse stimuli ranging from soluble endocrine and
paracrine factors, to signaling molecules on neighboring cells. It is of great importance that …
paracrine factors, to signaling molecules on neighboring cells. It is of great importance that …
Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice
M Rosell, M Kaforou, A Frontini… - American Journal …, 2014 - journals.physiology.org
Brown adipocytes dissipate energy, whereas white adipocytes are an energy storage site.
We explored the plasticity of different white adipose tissue depots in acquiring a brown …
We explored the plasticity of different white adipose tissue depots in acquiring a brown …
Epidermal growth factor receptor: mechanisms of activation and signalling
RN Jorissen, F Walker, N Pouliot, TPJ Garrett… - The EGF receptor …, 2003 - Elsevier
Publisher Summary This chapter discusses the structure and function of the epidermal
growth factor (EGF) receptor (EGFR), from ligand binding to the initiation of intracellular …
growth factor (EGF) receptor (EGFR), from ligand binding to the initiation of intracellular …
The epidermal growth factor receptor family: biology driving targeted therapeutics
MJ Wieduwilt, MM Moasser - Cellular and molecular life sciences, 2008 - Springer
The epidermal growth factor family of receptor tyrosine kinases (ErbBs) plays essential roles
in regulating cell proliferation, survival, differentiation and migration. The ErbB receptors …
in regulating cell proliferation, survival, differentiation and migration. The ErbB receptors …
Neuregulins: functions, forms, and signaling strategies
DL Falls - The EGF Receptor Family, 2003 - Elsevier
Publisher Summary This chapter focuses on neuregulins (NRGs) that are the signaling
proteins that mediate cell–cell interactions in the nervous system, heart, breast, and other …
proteins that mediate cell–cell interactions in the nervous system, heart, breast, and other …
The EGF receptor family as targets for cancer therapy
J Mendelsohn, J Baselga - Oncogene, 2000 - nature.com
Human carcinomas frequently express high levels of receptors in the EGF receptor family,
and overexpression of at least two of these receptors, the EGF receptor (EGFr) and closely …
and overexpression of at least two of these receptors, the EGF receptor (EGFr) and closely …