Antibiotic combination therapy against resistant bacterial infections: synergy, rejuvenation and resistance reduction

ARM Coates, Y Hu, J Holt, P Yeh - Expert review of Anti-infective …, 2020 - Taylor & Francis
ABSTRACT Introduction: Anti-Microbial Resistance (AMR) is a pandemic which threatens
modern medicine. There is a lack of effective drug treatment due to the slow pace, high cost …

How antibiotics work together: molecular mechanisms behind combination therapy

GJ Sullivan, NN Delgado, R Maharjan… - Current opinion in …, 2020 - Elsevier
Highlights•Combination therapy is an important tool for tackling antibiotic resistance.•In
depth molecular studies for combination therapy are lacking.•We summarise six major …

Deciphering of microbial community and antibiotic resistance genes in activated sludge reactors under high selective pressure of different antibiotics

R Zhao, J Feng, J Liu, W Fu, X Li, B Li - Water Research, 2019 - Elsevier
Currently, the effects of high antibiotic concentrations on the performance of microbiota and
antibiotic resistance genes (ARGs) in activated sludge (AS) process are not well …

Can microorganisms develop resistance against light based anti-infective agents?

S Marasini, LG Leanse, T Dai - Advanced Drug Delivery Reviews, 2021 - Elsevier
Recently, there have been increasing numbers of publications illustrating the potential of
light-based antimicrobial therapies to combat antimicrobial resistance. Several modalities, in …

Microbial interspecies interactions and their impact on the emergence and spread of antimicrobial resistance

G De Wit, L Svet, B Lories… - Annual Review of …, 2022 - annualreviews.org
Bacteria are social organisms that commonly live in dense communities surrounded by a
multitude of other species. The competitive and cooperative interactions between these …

[HTML][HTML] Environmental risks in swine biogas slurry-irrigated soils: A comprehensive analysis of antibiotic residues, resistome, and bacterial pathogens

JY Zeng, M Meng, L Qi, Y Li, H Yao - Environment International, 2024 - Elsevier
Simple anaerobic digestion is insufficient to completely remove residual parent antibiotics
and antibiotic resistance genes (ARGs) from animal manure. ARG prevalence in swine …

Inhalable liposomal powder formulations for co-delivery of synergistic ciprofloxacin and colistin against multi-drug resistant gram-negative lung infections

S Yu, S Wang, P Zou, G Chai, YW Lin, T Velkov… - International journal of …, 2020 - Elsevier
The aim of this study was to design and characterize dry powder inhaler formulations of
ciprofloxacin and colistin co-loaded liposomes prepared by the ultrasonic spray-freeze …

Development of Staphylococcus aureus tolerance to antimicrobial photodynamic inactivation and antimicrobial blue light upon sub-lethal treatment

A Rapacka-Zdonczyk, A Wozniak, M Pieranski… - Scientific Reports, 2019 - nature.com
Antimicrobial photodynamic inactivation (aPDI) and antimicrobial blue light (aBL) are
considered low-risk treatments for the development of bacterial resistance and/or tolerance …

Toward prediction and control of antibiotic-resistance evolution

C Furusawa, T Horinouchi, T Maeda - Current opinion in biotechnology, 2018 - Elsevier
Highlights•Laboratory evolution has provided detailed information on the evolution of drug
resistance.•Phenotype/genotype data reveal evolutionary constraint in the development of …

[HTML][HTML] Antibiofilm Effect of Biogenic Silver Nanoparticles Combined with Oregano Derivatives against Carbapenem-Resistant Klebsiella pneumoniae

S Scandorieiro, FMMB Teixeira, MCL Nogueira… - Antibiotics, 2023 - mdpi.com
Resistant bacteria may kill more people than COVID-19, so the development of new
antibacterials is essential, especially against microbial biofilms that are reservoirs of …