Whereas selenium was found to act as an insulin mimic and to be antidiabetic in earlier
studies, recent animal experiments and human trials have shown an unexpected risk of …

Cardiovascular dysfunction is leading cause for the mortality of diabetic individuals, in part
due to a specific cardiomyopathy, and due to altered endothelial dependent/independent …

Intracellular free zinc concentration ([Zn2+] i) is very important for cell functions, and its
excessive accumulation is cytotoxic.[Zn2+] i can increase rapidly in cardiomyocytes because …

Defective cardiac mechanical activity in diabetes results from alterations in intracellular
Ca2+ handling, in part, due to increased oxidative stress. Beta-blockers demonstrate …

Excessive selenium (Se) intake is harmful for animals and humans. The aim of the present
study was to examine the effect of long-term excessive Se supplementation on oxidative …

Cardiovascular disease is one of the most important causes of morbidity and mortality in
Western countries. In addition, it is well documented that selenium (Se) deficiency has been …

An important energy supplier of cardiomyocytes is mitochondria, similar to other mammalian
cells. Studies have demonstrated that any defect in the normal processes controlled by …

Adriamycin (ADR) causes morphological and functional alterations in mitochondrial
structure in the heart. The study′ s aim was to determine whether there is a protective effect …

Diabetes mellitus is a major risk factor for cardiovascular complications. Intracellular Ca2+
release plays an important role in the regulation of muscle contraction. Sarcoplasmic …

Numerous studies have found that high Selenium (Se) influences the pancreas in animals.
Considerable studies suggest that Se status plays an important role in the pancreatic …