Drug designing and development is an important area of research for pharmaceutical
companies and chemical scientists. However, low efficacy, off-target delivery, time …

Background Repurposing is a drug development strategy receiving heightened attention
after the Food and Drug Administration granted emergency use authorization of several …

Highlights•Hydrogel-based drug delivery systems can be more efficacious than the systemic
therapies.•They provide a high concentration and a sustained release of the drugs at tumor …

Highlights•Drug repositioning and similar terms have been a trending topic since
2004.•From a legal or regulatory perspective stimulation of drug repositioning requires …

Cancer management is major concern of health organizations and viral cancers account for
approximately 15.4% of all known human cancers. Due to large number of patients, efficient …

Non-small cell lung cancer (NSCLC) is one of the major cancer-related causes of morbidity
and mortality worldwide. Despite the progress in lung cancer treatment, there is still an …

Ivermectin is a macrolide antiparasitic drug with a 16-membered ring that is widely used for
the treatment of many parasitic diseases such as river blindness, elephantiasis and scabies …

The aim of this review is to critically analyze promises and limitations of pharmacological
inducers of autophagy against protein misfolding-associated neurodegeneration. Effective …

Cancer, a complex and multifactorial disease, presents a significant challenge to global
health. Despite significant advances in surgical, radiotherapeutic and immunological …

Repurposing approved non-antitumor drugs is a promising and affordable strategy in drug
discovery to identify new therapeutic uses different from the original medical indication that …