Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Chronic myeloid leukemia (CML) has been a “model disease” with a long history. Beginning
with the first discovery of leukemia and the description of the Philadelphia Chromosome and …

The sirtuins (SIRTs; of which there are seven in mammals) are NAD+-dependent enzymes
that regulate a large number of cellular pathways and forestall the progression of ageing …

Sirtuins are NAD+-dependent histone deacetylases regulating important metabolic
pathways in prokaryotes and eukaryotes and are involved in many biological processes …

Regulatory role of Sirtuin 1 (SIRT1), one of the most extensively studied members of its kind
in histone deacetylase family in governing multiple cellular fates, is predominantly linked to …

Chronic myeloid leukemia (CML) is caused by BCRABL1 in a cell with the biological
potential, intrinsic or acquired, to cause leukemia. This cell is commonly termed the CML …

Cardiovascular disease (CVD) due to atherosclerosis is the main cause of death in both the
elderly and patients with metabolic diseases, including diabetes. Aging processes contribute …

Sirtuins are a class of NAD+-dependent deacetylases having beneficial health effects. This
extensive review describes the numerous intracellular actions of the seven mammalian …

Whether cancer is maintained by a small number of stem cells or is composed of
proliferating cells with approximate phenotypic equivalency is a central question in cancer …