The eye is a sensory organ exposed to the environment and protected by a mucosal tissue
barrier. While it shares a number of features with other mucosal tissues, the ocular mucosal …

Since the last century, advances in healthcare, housing, and education have led to an
increase in life expectancy. Longevity is accompanied by a higher prevalence of age-related …

Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype. Recent
studies have shown that MHC class II (MHCII) expression and tumor infiltrating lymphocytes …

Chronic inflammation in tissues often causes the development of hypoxia. Herpes stromal
keratitis (HSK) is a corneal chronic inflammatory condition that develops in response to …

Diabetes mellitus is the most common cause of blindness in working age populations
worldwide. While much of the focus for public health has been on secondary prevention in …

Whether complement dysregulation directly contributes to the pathogenesis of peripheral
nervous system diseases, including sensory neuropathies, is unclear. We addressed this …

Tissue-resident memory T cells (TRM) were first described in 2009. While initially the major
focus was on CD8+ TRM, there has recently been increased interest in defining the …

In this paper, we use RNAseq to identify senescence and phagocytosis as key factors to
understanding how mitomyin C (MMC) stimulates regenerative wound repair. We use …

Ocular pathology is often associated with acute herpes simplex virus (HSV)-1 infection of the
cornea in mice. The present study was undertaken to determine the role of early T …

Purpose: Corneal opacity and neovascularization (NV) are often described as outcomes of
severe herpes simplex virus type 1 (HSV-1) infection. The current study investigated the role …