[HTML][HTML] Polyoxovanadates with emerging biomedical activities
Polyoxovanadates (POVs) are a subclass of a larger family of polyanionic group V and VI
metal-oxo clusters that are known as polyoxometalates (POMs). POMs have been found to …
metal-oxo clusters that are known as polyoxometalates (POMs). POMs have been found to …
Molecular mechanisms and clinical implications of the gold drug auranofin
S Shen, J Shen, Z Luo, F Wang, J Min - Coordination Chemistry Reviews, 2023 - Elsevier
Auranofin (AUR) is an orally available lipophilic gold-based anti-inflammatory compound
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …
Metallodrug Profiling against SARS‐CoV‐2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain‐like Protease PLpro
M Gil‐Moles, S Türck, U Basu… - … A European Journal, 2021 - Wiley Online Library
The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
has called for an urgent need for dedicated antiviral therapeutics. Metal complexes are …
has called for an urgent need for dedicated antiviral therapeutics. Metal complexes are …
Biological activities of bismuth compounds: an overview of the new findings and the old challenges not yet overcome
JS Rosário, FH Moreira, LHF Rosa, W Guerra… - Molecules, 2023 - mdpi.com
Bismuth-based drugs have been used primarily to treat ulcers caused by Helicobacter pylori
and other gastrointestinal ailments. Combined with antibiotics, these drugs also possess …
and other gastrointestinal ailments. Combined with antibiotics, these drugs also possess …
Metal complexes as antiviral agents for SARS‐CoV‐2
The severe acute respiratory syndrome–coronavirus 2 (SARS‐CoV‐2), the infectious agent
responsible for COVID‐19–has caused more than 2.5 million deaths worldwide and …
responsible for COVID‐19–has caused more than 2.5 million deaths worldwide and …
[HTML][HTML] Auranofin: Past to Present, and repurposing
M Yamashita - International Immunopharmacology, 2021 - Elsevier
Auranofin (AF), a gold compound, has been used to treat rheumatoid arthritis (RA) for more
than 40 years; however, its mechanism of action remains unknown. We revealed that AF …
than 40 years; however, its mechanism of action remains unknown. We revealed that AF …
Metal-based strategies for the fight against COVID-19
The emerging COVID-19 pandemic caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has claimed over six million lives globally to date. Despite the …
coronavirus 2 (SARS-CoV-2) has claimed over six million lives globally to date. Despite the …
Beyond silver sulfadiazine: A dive into more than 50 years of research and development on metal complexes of sulfonamides in medicinal inorganic chemistry
JHB Nunes, DH Nakahata, PP Corbi… - Coordination Chemistry …, 2023 - Elsevier
Sulfonamides revolutionized the treatment and management of bacterial infections. Prontosil
was the very first synthetic antibacterial agent ever used in the clinics and its metabolite …
was the very first synthetic antibacterial agent ever used in the clinics and its metabolite …
Complexes of ruthenium (II) as promising dual-active agents against cancer and viral infections
Poor responses to medical care and the failure of pharmacological treatment for many high-
frequency diseases, such as cancer and viral infections, have been widely documented. In …
frequency diseases, such as cancer and viral infections, have been widely documented. In …
Enzymatic synthesis of chemical nuclease triplex-forming oligonucleotides with gene-silencing applications
B McGorman, NZ Fantoni, S O'Carroll… - Nucleic acids …, 2022 - academic.oup.com
Triplex-forming oligonucleotides (TFOs) are short, single-stranded oligomers that hybridise
to a specific sequence of duplex DNA. TFOs can block transcription and thereby inhibit …
to a specific sequence of duplex DNA. TFOs can block transcription and thereby inhibit …