γδ T Cells: First Line of Defense and Beyond

Y Chien, C Meyer, M Bonneville - Annual review of immunology, 2014 - annualreviews.org
γδ T cells, αβ T cells, and B cells are present together in all but the most primitive
vertebrates, suggesting that each population contributes to host immune competence …

γδ T cells in the tumor microenvironment—Interactions with other immune cells

KF Chan, JDG Duarte, S Ostrouska… - Frontiers in …, 2022 - frontiersin.org
A growing number of studies have shown that γδ T cells play a pivotal role in mediating the
clearance of tumors and pathogen-infected cells with their potent cytotoxic, cytolytic, and …

The intracellular B30. 2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human Vγ9Vδ2 T cells

A Sandstrom, CM Peigné, A Léger, JE Crooks… - Immunity, 2014 - cell.com
In humans, Vγ9Vδ2 T cells detect tumor cells and microbial infections, including
Mycobacterium tuberculosis, through recognition of small pyrophosphate containing organic …

The BLT Humanized Mouse Model as a Tool for Studying Human Gamma Delta T Cell-HIV Interactions In Vivo

S Biradar, Y Agarwal, MT Lotze, MT Bility… - Frontiers in …, 2022 - frontiersin.org
Gamma-delta (γδ) T cells recognize antigens in a major histocompatibility complex (MHC)
independent and have cytotoxic capability. Human immunodeficiency virus (HIV) infection …

γδ T cells: functional plasticity and heterogeneity

SR Carding, PJ Egan - Nature reviews immunology, 2002 - nature.com
Abstract γδ T cells remain an enigma. They are capable of generating more unique antigen
receptors than αβ T cells and B cells combined, yet their repertoire of antigen receptors is …

Recognition of stress-induced MHC molecules by intestinal epithelial γδ T cells

V Groh, A Steinle, S Bauer, T Spies - Science, 1998 - science.org
T cells with variable region Vδ1 γδ T cell receptors (TCRs) are distributed throughout the
human intestinal epithelium and may function as sentinels that respond to self antigens. The …

Natural and synthetic non-peptide antigens recognized by human γδ T cells

Y Tanaka, CT Morita, Y Tanaka, E Nieves, MB Brenner… - Nature, 1995 - nature.com
T LYMPHOCYTES express either αβ or γδ T-cell receptor heterodimers1, 2. Most αβ T cells
recognize antigenic peptides bound to major histocompatibility complex molecules but the …

γδ cells: a right time and a right place for a conserved third way of protection

AC Hayday - Annual review of immunology, 2000 - annualreviews.org
The tripartite subdivision of lymphocytes into B cells, αβ T cells, and γδ cells has been
conserved seemingly since the emergence of jawed vertebrates, more than 450 million …

Stimulation of γδ T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma

V Kunzmann, E Bauer, J Feurle… - Blood, The Journal …, 2000 - ashpublications.org
Bisphosphonates are well-known inhibitors of osteoclastic bone resorption, but recent
clinical reports support the possibility of direct or indirect antitumor effects by these …

Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vγ2Vδ2 T cells: discriminating friend from foe through the recognition of prenyl …

CT Morita, C Jin, G Sarikonda… - Immunological reviews, 2007 - Wiley Online Library
Human Vγ2Vδ2 T cells play important roles in mediating immunity against microbial
pathogens and have potent anti‐tumor activity. Vγ2Vδ2 T cells recognize the …