KF Chan, JDG Duarte, S Ostrouska… - Frontiers in …, 2022 - frontiersin.org
A growing number of studies have shown that γδ T cells play a pivotal role in mediating the clearance of tumors and pathogen-infected cells with their potent cytotoxic, cytolytic, and …
A Sandstrom, CM Peigné, A Léger, JE Crooks… - Immunity, 2014 - cell.com
In humans, Vγ9Vδ2 T cells detect tumor cells and microbial infections, including Mycobacterium tuberculosis, through recognition of small pyrophosphate containing organic …
S Biradar, Y Agarwal, MT Lotze, MT Bility… - Frontiers in …, 2022 - frontiersin.org
Gamma-delta (γδ) T cells recognize antigens in a major histocompatibility complex (MHC) independent and have cytotoxic capability. Human immunodeficiency virus (HIV) infection …
Abstract γδ T cells remain an enigma. They are capable of generating more unique antigen receptors than αβ T cells and B cells combined, yet their repertoire of antigen receptors is …
V Groh, A Steinle, S Bauer, T Spies - Science, 1998 - science.org
T cells with variable region Vδ1 γδ T cell receptors (TCRs) are distributed throughout the human intestinal epithelium and may function as sentinels that respond to self antigens. The …
T LYMPHOCYTES express either αβ or γδ T-cell receptor heterodimers1, 2. Most αβ T cells recognize antigenic peptides bound to major histocompatibility complex molecules but the …
AC Hayday - Annual review of immunology, 2000 - annualreviews.org
The tripartite subdivision of lymphocytes into B cells, αβ T cells, and γδ cells has been conserved seemingly since the emergence of jawed vertebrates, more than 450 million …
V Kunzmann, E Bauer, J Feurle… - Blood, The Journal …, 2000 - ashpublications.org
Bisphosphonates are well-known inhibitors of osteoclastic bone resorption, but recent clinical reports support the possibility of direct or indirect antitumor effects by these …
CT Morita, C Jin, G Sarikonda… - Immunological reviews, 2007 - Wiley Online Library
Human Vγ2Vδ2 T cells play important roles in mediating immunity against microbial pathogens and have potent anti‐tumor activity. Vγ2Vδ2 T cells recognize the …