The cloning of leptin in 1994 was an important milestone in obesity research. In those days
obesity was stigmatized as a condition caused by lack of character and self-control …

Cross-talk between adipose tissue and central nervous system (CNS) underlies the
increased risk of obese people to develop brain diseases such as cognitive and mood …

Adipokines are currently widely studied cellular signaling proteins produced by adipose
tissue and involved in various processes, including inflammation; energy and appetite …

The increasing global prevalence of obesity and its associated disorders points to an urgent
need for the development of novel and effective therapeutic strategies that induce healthy …

Mutations in the gene encoding leptin (LEP) typically lead to an absence of circulating leptin
and to extreme obesity. We describe a 2-year-old boy with early-onset extreme obesity due …

Non-alcoholic fatty liver disease (NAFLD), which affects about a quarter of the global
population, poses a substantial health and economic burden in all countries, yet there is no …

Although growth hormone (GH) is a multifunctional factor that coordinates various aspects of
feeding, reproduction, osmoregulation, and immune system function, perhaps two of its most …

The intestines of obese humans and mice are enriched with Erysipelotrichi, a class within
the Firmicutes. Clostridium ramosum, a member of the Erysipelotrichi, is associated with …

Increasing adipose tissue mass in obesity directly correlates with elevated circulating leptin
levels. Leptin is an adipokine known to play a role in numerous biological processes …

Leptin is the primary adipostatic factor in mammals. Produced largely by adipocytes in
proportion to total adipose mass, the hormone informs the brain regarding total energy …