Two-pore channels (TPCs) are Ca 2+-permeable endo-lysosomal ion channels subject to
multi-modal regulation. They mediate their physiological effects through releasing Ca 2+ …

In this chapter we will review both the rationale and experimental design for using
Heterogeneous Stock (HS) populations for fine-mapping of complex traits in mice and rats …

Objective Obesity is a major risk factor for multiple diseases and is in part heritable, yet the
majority of causative genetic variants that drive excessive adiposity remain unknown. Here …

Due in part to their rich behavioral repertoire rats have been widely used in behavioral
studies of drug abuse-related traits for decades. However, the mouse became the model of …

Abstract The Collaborative Cross (CC) is an emerging panel of recombinant inbred (RI)
mouse strains. Each strain is genetically distinct but all descended from the same eight …

Clinical trials of tolvaptan showed it to be a promising candidate for the treatment of
Autosomal Dominant Polycystic Kidney Disease (ADPKD) but also revealed potential for …

Despite the successes of human genome-wide association studies, the causal genes
underlying most metabolic traits remain unclear. We used outbred heterogeneous stock …

Heterogeneous Stock (HS) populations allow for fine-resolution genetic mapping of a variety
of complex traits. HS mice and rats were created from breeding together eight inbred strains …

The genetic basis of type 2 diabetes remains incompletely defined despite the use of
multiple genetic strategies. Multiparental populations such as heterogeneous stocks (HS) …

Quantitative trait locus (QTL) mapping in animal populations has been a successful strategy
for identifying genomic regions that play a role in complex diseases and traits. When …